ArticleBiophysical journal2018
Co-Entangled Actin-Microtubule Composites Exhibit Tunable Stiffness and Power-Law Stress Relaxation.
Article in Biophysical journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Dissecting cytoskeletal crosstalk through reconstituted actin-microtubule systems.Molecular biology of the cell · 2026Review
- Kinesin-Driven De-Mixing of Cytoskeleton Composites Drives Emergent Mechanical Properties.Macromolecular rapid communications · 2025Article
- Interspecies interactions in dual, fibrous gels enable control of gel structure and rheology.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Phage probes couple to DNA relaxation dynamics to reveal universal behavior across scales and regimes.Soft matter · 2025Article
- Scale-dependent interactions enable emergent microrheological stress response of actin-vimentin composites.Soft matter · 2024Article
- How cytoskeletal crosstalk makes cells move: Bridging cell-free and cell studies.Biophysics reviews · 2024Review
- Multiscale elasticity mapping of biological samples in 3D at optical resolution.Acta biomaterialia · 2024Article
- Kinesin and myosin motors compete to drive rich multiphase dynamics in programmable cytoskeletal composites.PNAS nexus · 2023Article
- Nonlinear Microscale Mechanics of Actin Networks Governed by Coupling of Filament Crosslinking and Stabilization.Polymers · 2022Article
- Optical-Tweezers-integrating-Differential-Dynamic-Microscopy maps the spatiotemporal propagation of nonlinear strains in polymer blends and composites.Nature communications · 2022Article
- Multiscale architecture: Mechanics of composite cytoskeletal networks.Biophysics reviews · 2022Review
- Reconstituting and Characterizing Actin-Microtubule Composites with Tunable Motor-Driven Dynamics and Mechanics.Journal of visualized experiments : JoVE · 2022Article
- Topological digestion drives time-varying rheology of entangled DNA fluids.Nature communications · 2022Article
- Cell wall and cytoskeletal contributions in single cell biomechanics ofQuantitative plant biology · 2022Article
- DNA Conformation Dictates Strength and Flocculation in DNA-Microtubule Composites.ACS macro letters · 2021Article
- Active cytoskeletal composites display emergent tunable contractility and restructuring.Soft matter · 2021Article
- Motor-Driven Restructuring of Cytoskeleton Composites Leads to Tunable Time-Varying Elasticity.ACS macro letters · 2021Article
- Subtle changes in crosslinking drive diverse anomalous transport characteristics in actin-microtubule networks.Soft matter · 2021Article
- Myosin-driven actin-microtubule networks exhibit self-organized contractile dynamics.Science advances · 2021Article
- Triggering Cation-Induced Contraction of Cytoskeleton Networks via Microfluidics.Frontiers in physics · 2020Article
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3 authors.
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Abstract
We use optical tweezers microrheology and fluorescence microscopy to characterize the nonlinear mesoscale mechanics and mobility of in vitro co-entangled actin-microtubule composites. We create a suite of randomly oriented, well-mixed networks of actin and microtubules by co-polymerizing varying ratios of actin and tubulin in situ. To perturb each composite far from equilibrium, we use optical tweezers to displace an embedded microsphere a distance greater than the lengths of the filaments at a speed much faster than their intrinsic relaxation rates. We simultaneously measure the force the filaments exert on the bead and the subsequent force relaxation. We find that the presence of a large fraction of microtubules (>0.7) is needed to substantially increase the measured force, which is accompanied by large heterogeneities in force response. Actin minimizes these heterogeneities by reducing the mesh size of the composites and supporting microtubules against buckling. Composites also undergo a sharp transition from strain softening to stiffening when the fraction of microtubules (ϕ
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