Evidence map›Paper›PMID 30177276›Full record

SynthesisAlzheimer's & dementia : the journal of the Alzheimer's Association2018

Stroke and dementia risk: A systematic review and meta-analysis.

Elżbieta Kuźma, Ilianna Lourida, Sarah F Moore, Deborah A Levine, Obioha C Ukoumunne, David J Llewellyn

Abstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 199 papers, 16 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
199citing papers in PubMed, 16 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

199 citing papers in PubMed, 16 syntheses or guidelines pooled it.

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  13. Cognitive impairment in sporadic cerebral small vessel disease: A systematic review and meta-analysis.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2021
    Pooled it
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  19. Clinical modifiers of the association between type 1 diabetes and dementia incidence.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  20. Aging with dual burdens: cross-national evidence on mortality among older Hispanic adults with diabetes and dementia.The journals of gerontology. Series B, Psychological sciences and social sciences · 2026
    Article

139 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Elżbieta KuźmaUniversity of Exeter Medical School, St Luke's Campus, Exeter, UK.
Ilianna LouridaUniversity of Exeter Medical School, St Luke's Campus, Exeter, UK.
Sarah F MooreUniversity of Exeter Medical School, St Luke's Campus, Exeter, UK.
Deborah A LevineDepartment of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA; Institute for Healthcare Policy and Innovation, University of Michigan, Ann Arbor, MI, USA; Department of Neurology and Stroke Program, University of Michigan, Ann Arbor, MI, USA.
Obioha C UkoumunneNIHR CLAHRC South West Peninsula (PenCLAHRC), University of Exeter Medical School, St Luke's Campus, Exeter, UK.
David J LlewellynUniversity of Exeter Medical School, St Luke's Campus, Exeter, UK. Electronic address: david.llewellyn@exeter.ac.uk.

Funding

Identifying modifiable aspects of gene-by-environment interplay in later-life cognitive declineRF1AG055654 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI FAUL, JESSICA, GALAMA, TITUS JOHANNES · 2017 to 2018
$4.3M
The Effect of Lower Blood Pressure over the Life Course on Late-life Cognition in Blacks, Hispanics, and Whites (BP-COG)R01NS102715 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LEVINE, DEBORAH ALLISON · 2017 to 2021
$3.8M
Decision Making for Cardiovascular Therapy in Adults with Mild Cognitive ImpairmentR01AG051827 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LEVINE, DEBORAH ALLISON · 2016 to 2020
$3.6M
NIA NIH HHS R01 AG051827NIA NIH HHS RF1 AG055654NINDS NIH HHS R01 NS102715
6 · The paper itself

Abstract

introductionStroke is an established risk factor for all-cause dementia, though meta-analyses are needed to quantify this risk.

methodsWe searched Medline, PsycINFO, and Embase for studies assessing prevalent or incident stroke versus a no-stroke comparison group and the risk of all-cause dementia. Random effects meta-analysis was used to pool adjusted estimates across studies, and meta-regression was used to investigate potential effect modifiers.

resultsWe identified 36 studies of prevalent stroke (1.9 million participants) and 12 studies of incident stroke (1.3 million participants). For prevalent stroke, the pooled hazard ratio for all-cause dementia was 1.69 (95% confidence interval: 1.49-1.92; P < .00001; I DISCUSSION: Stroke is a strong, independent, and potentially modifiable risk factor for all-cause dementia.

Indexed as

CognitionAgedAge FactorsCognitive DysfunctionCohort StudiesDementiaDiabetes MellitusFemaleFollow-Up StudiesHumansMaleMiddle AgedObesityPrevalenceRisk FactorsVascular Diseases

Identifiers

PMID30177276
PMCPMC6231970

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.