ArticleJournal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine2018
Obesity Hypoventilation Syndrome: Early Detection of Nocturnal-Only Hypercapnia in an Obese Population.
Article in Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 31 citations in OpenAlex.
- Predictors of sleep-disordered breathing and chronic hypoventilation in obese women and men: a cross-sectional observational study.BMJ open respiratory research · 2025Observational
- Pulmonary Function and Nocturnal Hypoxemia Patterns in Patients with Obstructive Sleep Apnea.Journal of clinical medicine · 2025Article
- Hypoxia modeling techniques: A review.Heliyon · 2023Review
- Nocturnal Hypoventilation in the Patients Submitted to Thoracic Surgery.Canadian respiratory journal · 2023Article
- Obesity-associated sleep hypoventilation and increased adverse postoperative bariatric surgery outcomes in a large clinical retrospective cohort.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2022Article
- Fusion of Whole Night Features and Desaturation Segments Combined with Feature Extraction for Event-Level Screening of Sleep-Disordered Breathing.Nature and science of sleep · 2022Article
- Evaluation of the Effects of Noninvasive Ventilation on Blood Gas and Depression Levels of Patients with Obesity Hypoventilation Syndrome.Advanced biomedical research · 2022Article
- Defining obesity hypoventilation syndrome.Breathe (Sheffield, England) · 2021Review
- Overlooking Obesity Hypoventilation Syndrome: The Need for Obesity Hypoventilation Syndrome Staging and Risk Stratification.Annals of the American Thoracic Society · 2020Article
- Predicting CPAP failure in patients with suspected sleep hypoventilation identified on ambulatory testing.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2020Article
- Effects of Intermittent Hypoxia on Pulmonary Vascular and Systemic Diseases.International journal of environmental research and public health · 2019Review
- Obesity Hypoventilation Syndrome: Will Early Detection and Effective Therapy Improve Long-Term Outcomes?Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2018Article
- Predictors of obesity hypoventilation syndrome among patients with sleep-disordered breathing in India.Lung India : official organ of Indian Chest SocietyArticle
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
STUDY
objectivesHypoventilation in obesity is now divided into five stages; stage 0 (pure obstructive sleep apnea; OSA), stages I/II (obesity-related sleep hypoventilation; ORSH) and stages III/IV (awake hypercapnia, obesity hypoventilation syndrome; OHS). Hypercapnia during the day may be preceded by hypoventilation during sleep. The goal of this study was to determine the prevalence and to identify simple clinical measures that predict stages I/II ORSH. The effect of supine positioning on selected clinical measures was also evaluated.
methodsNinety-four patients with a body mass index > 40 kg/m
resultsStages I/II ORSH had a prevalence of 19% in an outpatient tertiary hospital setting compared with 61%, 17%, and 3% for stages 0, III/IV, and no sleep-disordered breathing respectively. Predictors for sleep hypoventilation in this group were an awake oxygen saturation of ≤ 93% (sensitivity 39%, specificity 98%, positive likelihood ratio of 22) and a partial pressure of carbon dioxide ≥ 45 mmHg (sensitivity 44%, specificity 98%, positive likelihood ratio of 24) measured in the supine position.
conclusionsORSH has a similar prevalence to OHS. Awake oxygen saturation and partial pressure of carbon dioxide performed in the supine position may help predict obese patients with sleep hypoventilation without awake hypercapnia. COMMENTARY: A commentary on this article appears in this issue on page 1455. CLINICAL
trial registrationRegistry: Australian New Zealand Clinical Trials Registry, Identifier: ACTRN 12615000135516, URL: https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=367493&isReview=true, Title: A cross-sectional study to identify obese patients who are at risk for developing obesity hypoventilation syndrome (OHS) by investigating the relationship between daytime measures (including supine hypercapnia, distribution of body fat and lung volumes) with the presence of hypoventilation during sleep.
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