Evidence map›Paper›PMID 30176931›Full record

ArticleActa neuropathologica communications2018

Hypoxic pre-conditioning suppresses experimental autoimmune encephalomyelitis by modifying multiple properties of blood vessels.

Sebok K Halder, Ravi Kant, Richard Milner

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta neuropathologica communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Hypoxia in multiple sclerosis.Redox biology · 2025
    Review
  3. The importance of laminin at the blood-brain barrier.Neural regeneration research · 2023
    Review
  4. Review
  5. Review
  6. Review
  7. Article
  8. Article
  9. A critical role for microglia in maintaining vascular integrity in the hypoxic spinal cord.Proceedings of the National Academy of Sciences of the United States of America · 2019
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Sebok K HalderDepartment of Molecular Medicine, MEM-151, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, 92037, USA.
Ravi KantDepartment of Molecular Medicine, MEM-151, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, 92037, USA.
Richard MilnerDepartment of Molecular Medicine, MEM-151, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, 92037, USA. rmilner@scripps.edu.
Scripps Research Institute · US

Funding

The protective potential of mild hypoxia on inflammatory demyelinating diseaseR56NS095753 · NINDS · SCRIPPS RESEARCH INSTITUTE, THE · PI MILNER, D. RICHARD · 2016 to 2016
$385k
NINDS NIH HHS R56 NS095753
6 · The paper itself

Abstract

While hypoxic pre-conditioning protects against neurological disease the underlying mechanisms have yet to be fully defined. As chronic mild hypoxia (CMH, 10% O

Indexed as

AnimalsAntigens, CDAntigens, SurfaceCollagen Type IVDisease Models, AnimalEncephalomyelitis, Autoimmune, ExperimentalFemaleFibrinogenFreund's AdjuvantGene Expression RegulationIschemic PreconditioningLamininMiceMyelin Proteolipid ProteinOccludinPeptide FragmentsAntigens, CDAntigens, SurfaceCollagen Type IVFibrinogenFreund's AdjuvantLamininMECA-32 antigen, mouseMyelin Proteolipid Proteinmyelin proteolipid protein (139-151)OccludinPeptide FragmentsTjp1 protein, mouseVascular Cell Adhesion Molecule-1Zonula Occludens-1 ProteinBlood-brain barrierEndothelialExperimental autoimmune encephalomyelitisHypoxic pre-conditioningLaminin

Identifiers

PMID30176931
PMCPMC6122733
OpenAlexW2889255024

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.