ArticleBMC cancer2018
Prognostic value of differentiation status in gastric cancer.
Article in BMC cancer, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.
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Who cites it
46 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prognostic factors for resected invasive mucinous lung adenocarcinoma: a systematic review and meta-analysis.BMC cancer · 2024Pooled it
- Analysis of endoscopic and pathological features of 6961 cases of gastric cancer.Scientific reports · 2024Trial
- Major Histocompatibility Complex Class I-Related Chain A (MICA) Allelic Variants Associate With Susceptibility and Prognosis of Gastric Cancer.Frontiers in immunology · 2021Trial
- High Prevalence of Clinical Understaging in Early Gastric Cancer: An Analysis of the NCDB.Annals of surgical oncology · 2026Article
- CT radiomics for noninvasive prediction of histologic differentiation in gastric cancer.Medical physics · 2026Article
- Serum microRNA Profiles Reflect Differentiation Status and Age in Early Gastric Cancer.Biomolecules · 2026Article
- Genomic Landscape of Poorly Differentiated Gastric Carcinoma: An AACR GENIELife (Basel, Switzerland) · 2026Article
- Clinicopathological characteristics and prognostic model validation for mucinous gastric carcinoma.Scientific reports · 2026Article
- Expression of p53 and p63 proteins and their correlation with histological grades among gastric carcinoma specimens at Mbarara Regional Referral Hospital.African journal of laboratory medicine · 2026Article
- Preoperative prediction of tumor deposits in advanced gastric cancer using intratumoral and peritumoral CT radiomics: development and validation of an ensemble model.Frontiers in oncology · 2026Article
- Differentiating the differentiation degree of gastric cancer based on MRI radiomics.BMC medical imaging · 2025Article
- Article
- Prognostic factors in gastric cancer survivors comparing Cox proportional hazards and machine learning using a Korean National cohort.Discover oncology · 2025Article
- Association between FGF10 expression and gland-forming differentiation pattern in gastric adenocarcinoma: An immunohistochemical analysis.Oncology letters · 2025Article
- A hybrid multi-instance learning-based identification of gastric adenocarcinoma differentiation on whole-slide images.Biomedical engineering online · 2025Article
- Evaluating log odds of positive lymph nodes as a prognostic tool in differentiated gastric cancer: A retrospective study.World journal of gastroenterology · 2025Article
- Development of a prognostic nomogram and risk factor analysis for survival inTranslational cancer research · 2025Article
- Comparison of Clinical Parameters, Histopathological Features and Status of Intraoperative Surgical Margins Between Recurrent and Non-Recurrent Oral Squamous Cell Carcinoma.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2025Article
- The plasticity of epithelial cells and its potential in the induced differentiation of gastric cancer.Cell death discovery · 2024Review
- Predicting gastric cancer response to anti-HER2 therapy or anti-HER2 combined immunotherapy based on multi-modal data.Signal transduction and targeted therapy · 2024Article
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10 authors.
Funding
Abstract
backgroundUp to date, investigation of the prognostic value of differentiation status mainly focused on signet ring cell and mucinous gastric cancer. Thus, the present study aims to investigate the clinicopathological features and prognosis of gastric cancer patients with well, moderately and poorly differentiation status.
methodsFrom September 2008 to March 2015, a total of 3090 gastric cancer patients treated with radical D2 gastrectomy were enrolled in the present study. Clinicopathological characteristics and prognosis of gastric cancer patients with well, moderately and poorly differentiation status were analyzed.
resultsThere were 2422 male (78.4%) and 668 female (21.6%). The median age was 58 (20-90) years. There were 370 (12.0%) well differentiated tumors, 836 (27.0%) moderately differentiated tumors and 1884 (61.0%) poorly differentiated tumors. Well and moderately differentiation status were associated with older age, male gender, smaller tumor, shallower invasion, less lymph node involvement and earlier tumor stage (all p < 0.001). Inversely, poorly differentiation status was associated with younger age, female gender, larger tumor, deeper invasion, more lymph node involvement and later tumor stage (all p < 0.001). With respect to prognosis, well differentiation status was associated with favorable overall survival and poorly differentiation status was associated with unfavorable overall survival (p < 0.001). However, after matching with age, tumor size, T and N stage, there was no significant difference among the overall survival of the three groups (p = 0.415).
conclusionsWell, moderately and poorly differentiation status was significantly associated with clinicopathological features of gastric cancer patients. However, it was not associated with the prognosis of gastric cancer patients.
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