ArticlePsychiatry investigation2019
Fear Network Model in Panic Disorder: The Past and the Future.
Article in Psychiatry investigation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Grey matter structural alterations in anxiety disorders: a voxel-based meta-analysis.Brain imaging and behavior · 2024Pooled it
- Gray Matter Alterations in Panic Disorder: A Voxel-Wise Meta-Analysis.Psychiatry and clinical psychopharmacology · 2023Pooled it
- Evidence from EEG of Abnormal Functional Connectivity and Microstates in GAD and PD.Brain topography · 2026Article
- Alterations of Cortical Thickness in High Suicidality Patients with Panic Disorder and Their Relationship with Symptomatology and Treatment Response.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2026Article
- Neurostructural Substrates of Hierarchical Dimensions of Internalizing Symptoms in Youth.Human brain mapping · 2026Article
- Pre-pandemic brain structure and COVID-19 fear: insights into posttraumatic stress and general distress.Frontiers in psychiatry · 2025Article
- Brain Mechanisms Underlying Panic Attack and Panic Disorder.Neuroscience bulletin · 2024Review
- Enhanced interhemispheric resting-state functional connectivity of the visual network is an early treatment response of paroxetine in patients with panic disorder.European archives of psychiatry and clinical neuroscience · 2024Article
- Brain function abnormalities and inflammation in HIV-positive men who have sex with men with depressive disorders.Frontiers in psychiatry · 2024Article
- Sex differences in the effects of trait anxiety and age on resting-state functional connectivities of the amygdala.Journal of affective disorders reports · 2023Article
- Breaking the Fear Barrier: Aberrant Activity of Fear Networks as a Prognostic Biomarker in Patients with Panic Disorder Normalized by Pharmacotherapy.Biomedicines · 2023Article
- Structural connectome alterations in anxious dogs: a DTI-based study.Scientific reports · 2023Article
- Changes in brain rhythms and connectivity tracking fear acquisition and reversal.Brain structure & function · 2023Article
- Altered White Matter Network Topology in Panic Disorder.Journal of personalized medicine · 2023Article
- Alteration of static and dynamic intrinsic brain activity induced by short-term spinal cord stimulation in postherpetic neuralgia patients.Frontiers in neuroscience · 2023Article
- Neuroanatomy of post-stroke depression: the association between symptom clusters and lesion location.Brain communications · 2023Article
- A Voxel-Based Morphometric Study of Gray Matter in Specific Phobia.Life (Basel, Switzerland) · 2022Article
- Disrupted fronto-temporal function in panic disorder: a resting-state connectome study.Brain imaging and behavior · 2022Article
- Glutamic Acid Decarboxylase 1 Gene Methylation and Panic Disorder Severity: Making the Connection by Brain Gray Matter Volume.Frontiers in psychiatry · 2022Article
- Alterations in local activity and functional connectivity in patients with postherpetic neuralgia after short-term spinal cord stimulation.Frontiers in molecular neuroscience · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The core concept for pathophysiology in panic disorder (PD) is the fear network model (FNM). The alterations in FNM might be linked with disturbances in the autonomic nervous system (ANS), which is a common phenomenon in PD. The traditional FNM included the frontal and limbic regions, which were dysregulated in the feedback mechanism for cognitive control of frontal lobe over the primitive response of limbic system. The exaggerated responses of limbic system are also associated with dysregulation in the neurotransmitter system. The neuroimaging studies also corresponded to FNM concept. However, more extended areas of FNM have been discovered in recent imaging studies, such as sensory regions of occipital, parietal cortex and temporal cortex and insula. The insula might integrate the filtered sensory information via thalamus from the visuospatial and other sensory modalities related to occipital, parietal and temporal lobes. In this review article, the traditional and advanced FNM would be discussed. I would also focus on the current evidences of insula, temporal, parietal and occipital lobes in the pathophysiology. In addition, the white matter and functional connectome studies would be reviewed to support the concept of advanced FNM. An emerging dysregulation model of fronto-limbic-insula and temporooccipito-parietal areas might be revealed according to the combined results of recent neuroimaging studies. The future delineation of advanced FNM model can be beneficial from more extensive and advanced studies focusing on the additional sensory regions of occipital, parietal and temporal cortex to confirm the role of advanced FNM in the pathophysiology of PD.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.