ArticleJournal of innate immunity2019
Candida: Platelet Interaction and Platelet Activity in vitro.
Article in Journal of innate immunity, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Emergence and Comparative Analysis ofJournal of fungi (Basel, Switzerland) · 2026Article
- Beyond hemostasis, the immunomodulatory nature of platelets.Research and practice in thrombosis and haemostasis · 2025Review
- Antifungal Innate Immunity.Advances in experimental medicine and biology · 2025Review
- Invasive candidiasis.Nature reviews. Disease primers · 2024Review
- Rapid detection of pathogenic fungi from coastal population with respiratory infections using microfluidic chip technology.BMC infectious diseases · 2024Article
- [Research on immunological function of platelet receptor FcγRⅡA].Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi · 2023Article
- Article
- A new model for predicting the outcome and effectiveness of drug therapy in patients with severe fever with thrombocytopenia syndrome: A multicenter Chinese study.PLoS neglected tropical diseases · 2023Article
- Machine Learning in Infectious Disease for Risk Factor Identification and Hypothesis Generation: Proof of Concept Using Invasive Candidiasis.Open forum infectious diseases · 2022Article
- Mortality-associated factors of candidemia: a multi-center prospective cohort in Turkey.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2022Observational
- In vitro infection models to study fungal-host interactions.FEMS microbiology reviews · 2021Review
- Immune Sensing ofJournal of fungi (Basel, Switzerland) · 2021Review
- GP IIb/IIIa-Mediated Platelet Activation and Its Modulation of the Immune Response of Monocytes AgainstFrontiers in cellular and infection microbiology · 2021Article
- Antibacterial Properties of Canine Platelet-Rich Plasma and Other Non-Transfusional Hemo-Components: AnFrontiers in veterinary science · 2021Article
- Stepping Up to the Plate(let) against Candida albicans.Infection and immunity · 2020Article
- Who is WHO?Journal of innate immunity · 2020Article
- Significant Differences in Host-Pathogen Interactions Between Murine and Human Whole Blood.Frontiers in immunology · 2020Article
- Serious, Severe, Sepsis.Journal of innate immunity · 2020Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Over the last 2 decades, platelets have been recognized as versatile players of innate immunity. The interaction of platelets with fungal pathogens and subsequent processes may critically influence the clinical outcome of invasive mycoses. Since the role of platelets in Candida infections is poorly characterized and controversially discussed, we studied interactions of human platelets with yeast cells, (pseudo-)hyphae, biofilms and secretory products of human pathogenic Candida species applying platelet rich plasma and a whole blood model. Incubation of Candida with platelets resulted in moderate mutual interaction with some variation between different species. The rate of platelets binding to -Candida (pseudo-) hyphae and candidal biofilm was comparably low as that to the yeast form. Candida-derived secretory products did not affect platelet activity - neither stimulatory nor inhibitory. The small subset of platelets that bound to Candida morphotypes was consequently activated. However, this did not result in reduced growth or viability of the different Candida species. A whole blood model simulating in vivo conditions confirmed platelet activation in the subpopulation of Candida-bound platelets. Thus, the inability of platelets to efficiently react on Candida presence might favor fungal survival in the blood and contribute to high morbidity of Candida sepsis.
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Registered trials
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