ArticleDrug and alcohol dependence2018
Environmental enrichment reverses increased addiction risk caused by prenatal ethanol exposure.
Article in Drug and alcohol dependence, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Bored at home?-A systematic review on the effect of environmental enrichment on the welfare of laboratory rats and mice.Frontiers in veterinary science · 2022Pooled it
- Environmental enrichment reverses prenatal ethanol exposure-induced attention-deficits in rats.Frontiers in psychiatry · 2025Article
- The Fetal Alcohol Spectrum Disorders-An Overview of Experimental Models, Therapeutic Strategies, and Future Research Directions.Children (Basel, Switzerland) · 2024Review
- A bibliometric analysis of studies on environmental enrichment spanning 1967-2024: patterns and trends over the years.Frontiers in behavioral neuroscience · 2024Article
- Prenatal ethanol exposure leads to persistent anxiety-like behavior during adulthood indicated by reduced horizontal and vertical exploratory behaviors.Frontiers in neuroscience · 2023Article
- Prenatal ethanol exposure causes anxiety-like phenotype and alters synaptic nitric oxide and endocannabinoid signaling in dorsal raphe nucleus of adult male rats.Translational psychiatry · 2022Article
- Prenatal ethanol exposure impairs sensory processing and habituation to visual stimuli, effects normalized by enrichment of postnatal environmental.Alcoholism, clinical and experimental research · 2022Article
- Moderate prenatal ethanol exposure leads to attention deficits in both male and female rats.Alcoholism, clinical and experimental research · 2021Article
- Prenatal and postnatal alcohol exposure increases vulnerability to cocaine addiction in adult mice.British journal of pharmacology · 2020Article
- Prenatal Ethanol Exposure and Postnatal Environmental Intervention Alter Dopaminergic Neuron and Microglia Morphology in the Ventral Tegmental Area During Adulthood.Alcoholism, clinical and experimental research · 2020Article
- Environmental Enrichment During Adolescence Mitigates Cognitive Deficits and Alcohol Vulnerability due to Continuous and Intermittent Perinatal Alcohol Exposure in Adult Rats.Frontiers in behavioral neuroscience · 2020Article
- Enriched Environment Decreases Cognitive Impairment in Elderly Rats With Prenatal Mobile Phone Exposure.Frontiers in aging neuroscience · 2020Article
- Prenatal Ethanol Exposure Leads to Attention Deficits in Both Male and Female Rats.Frontiers in neuroscience · 2020Article
- Striatal morphological and functional alterations induced by prenatal alcohol exposure.Pharmacological research · 2019Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Prenatal ethanol exposure (PE) leads to multiple cognitive and behavioral deficits including increased drug addiction risk. Previous studies have shown that rearing environment plays a significant role in impacting addiction risk. In the present study, we investigated if environmental enrichment during development could be effective in lowering the PE-induced increase in addiction risk. To simulate heavy drinking during pregnancy in humans, pregnant Sprague-Dawley rats received ethanol (6 g/kg/day) or vehicle through intragastric gavage on gestation days 8-20. After weaning, the offspring were reared in either an enriched environment (EE) including neonatal handling and complex housing or an impoverished environment (IE) consisting of barren, single housing. Adult male offspring were then tested for locomotion, performance on the elevated plus maze, and amphetamine self-administration under a progressive ratio reinforcement schedule. Overall, EE rats, compared to IE rats, showed reduced locomotor activity in a novel environment and lower levels of anxiety, irrespective of prenatal treatments. Prenatal ethanol exposure increased amphetamine self-administration at both doses tested (0.02 and 0.05 mg/kg/infusion) and in each case EE, relative to IE, reversed this effect. These findings suggest that postnatal environmental complexity plays a determining role in addiction risk after PE.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.