ArticleNeuroscience2018
Stress Adaptation Upregulates Oxytocin within Hypothalamo-Vagal Neurocircuits.
Article in Neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 22 citations in OpenAlex.
- Oestrogen modulates stress-induced vagally-dependent gastric responses to oxytocin.The Journal of physiology · 2026Article
- Vagal control of the brain-esophagus axis ameliorates stress-induced esophageal motility dysfunction in male mice.Molecular metabolism · 2026Article
- Central control of gastrointestinal functions in health and disease.Physiological reviews · 2026Review
- Article
- Vagus nerve damage increases alcohol intake and preference in a nonpreferring rat line: Relationship to vagal regulation of the hypothalamic-pituitary-adrenal axis.Alcohol, clinical & experimental research · 2024Article
- Translational models of stress and resilience: An applied neuroscience methodology review.Neuroscience applied · 2024Review
- Perinatal high-fat diet exposure alters oxytocin and corticotropin releasing factor inputs onto vagal neurocircuits controlling gastric motility.The Journal of physiology · 2023Article
- Stress-induced neuroplasticity in the gastric response to brainstem oxytocin in male rats.American journal of physiology. Gastrointestinal and liver physiology · 2022Article
- Involvement of the Dorsal Vagal Complex in Alcohol-Related Behaviors.Frontiers in behavioral neuroscience · 2022Review
- Roles of Oxytocin in Stress Responses, Allostasis and Resilience.International journal of molecular sciences · 2021Review
- Oxytocin Signaling Acts as a Marker for Environmental Stressors in Zebrafish.International journal of molecular sciences · 2021Article
- Hypothalamic-vagal oxytocinergic neurocircuitry modulates gastric emptying and motility following stress.The Journal of physiology · 2020Article
- Oxytocin-monomeric red fluorescent protein 1 synthesis in the hypothalamus under osmotic challenge and acute hypovolemia in a transgenic rat line.Physiological reports · 2020Article
- Neuromechanism of acupuncture regulating gastrointestinal motility.World journal of gastroenterology · 2020Review
- Functional Status of Hypothalamic-Pituitary-Thyroid and Hypothalamic-Pituitary-Adrenal Axes in Hospitalized Schizophrenics in Shanghai.Frontiers in psychiatry · 2020Article
- Stress-induced modulation of vagal afferents.Neurogastroenterology and motility · 2019Review
- Role of estrogen and stress on the brain-gut axis.American journal of physiology. Gastrointestinal and liver physiology · 2019Review
- Central control of gastrointestinal motility.Current opinion in endocrinology, diabetes, and obesity · 2019Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Stress plays a pivotal role in the development and/or exacerbation of functional gastrointestinal (GI) disorders. The paraventricular nucleus of the hypothalamus (PVN) contains neurons that are part of the hypothalamic-pituitary-adrenal axis as well as preautonomic neurons innervating, among other areas, gastric-projecting preganglionic neurons of the dorsal vagal complex (DVC). The aim of the present study was to test the hypothesis that stress adaptation upregulates oxytocin (OXT) within PVN-brainstem vagal neurocircuitry. The retrograde tracer cholera toxin B (CTB) was injected into the DVC of rats which, after post-surgical recovery, were pair-housed and exposed to either homo- or heterotypic stress for five consecutive days. Fecal pellets were counted at the end of each stress load. Two hours after the last stressor, the whole brain was excised. Brainstem and hypothalamic nuclei were analyzed immunohistochemically for the presence of both OXT-immunopositive cells in identified preautonomic PVN neurons as well as OXT fibers in the DVC. Rats exposed to chronic homotypic, but not chronic heterotypic stress, had a significant increase in both number of CTB+ OXT co-localized neurons in the PVN as well as density of OXT-positive fibers in the DVC compared to control rats. These data suggest that preautonomic OXT PVN neurons and their projections to the DVC increase following adaptation to stress, and suggest that the possible up-regulation of OXT within PVN-brainstem vagal neurocircuitry may play a role in the adaptation of GI responses to stress.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.