ArticleAngewandte Chemie (International ed. in English)2018
Catalytic Promiscuity of Galactose Oxidase: A Mild Synthesis of Nitriles from Alcohols, Air, and Ammonia.
Article in Angewandte Chemie (International ed. in English), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 51 citations in OpenAlex.
- Light-driven toluene ammoxidation via mixture photocatalyst of halide perovskite CsScience advances · 2026Article
- Amide and Thioester Synthesis Via Oxidative Coupling of Alcohols with Amines or Thiols Using Alcohol Dehydrogenases.Angewandte Chemie (International ed. in English) · 2026Article
- Stable and Promiscuous Galactose Oxidases Engineered by Directed Evolution, Atomistic Design, and Ancestral Sequence Reconstruction.ACS synthetic biology · 2025Article
- Enzymatic properties of a non-classical aldoxime dehydratase capable of producing alkyl and arylalkyl nitriles.Applied microbiology and biotechnology · 2023Article
- Oxidative cleavage and ammoxidation of organosulfur compounds via synergistic Co-Nx sites and Co nanoparticles catalysis.Nature communications · 2023Article
- Organic Acid to Nitrile: A Chemoenzymatic Three-Step Route.Advanced synthesis & catalysis · 2023Article
- On the Mediated Electron Transfer of Immobilized Galactose Oxidase for Biotechnological Applications.Chemistry (Weinheim an der Bergstrasse, Germany) · 2022Article
- Tunable Production of (ACS catalysis · 2022Article
- Chemoenzymatic one-pot reaction from carboxylic acid to nitrileCatalysis science & technology · 2022Article
- Bioinspired Diversification Approach Toward the Total Synthesis of Lycodine-Type Alkaloids.Journal of the American Chemical Society · 2021Article
- Generation of Oxidoreductases with Dual Alcohol Dehydrogenase and Amine Dehydrogenase Activity.Chemistry (Weinheim an der Bergstrasse, Germany) · 2021Article
- The Hitchhiker's guide to biocatalysis: recent advances in the use of enzymes in organic synthesis.Chemical science · 2020Review
- Catalytic Oxidations in a Bio-Based Economy.Frontiers in chemistry · 2020Review
- Mechanistic Insight into the Catalytic Promiscuity of Amine Dehydrogenases: Asymmetric Synthesis of Secondary and Primary Amines.Chembiochem : a European journal of chemical biology · 2019Article
- Catalytic Promiscuity of Galactose Oxidase: A Mild Synthesis of Nitriles from Alcohols, Air, and Ammonia.Angewandte Chemie (International ed. in English) · 2018Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
We report an unprecedented catalytically promiscuous activity of the copper-dependent enzyme galactose oxidase. The enzyme catalyses the one-pot conversion of alcohols into the related nitriles under mild reaction conditions in ammonium buffer, consuming ammonia as the source of nitrogen and dioxygen (from air at atmospheric pressure) as the only oxidant. Thus, this green method does not require either cyanide salts, toxic metals, or undesired oxidants in stoichiometric amounts. The substrate scope of the reaction includes benzyl and cinnamyl alcohols as well as 4- and 3-pyridylmethanol, giving access to valuable chemical compounds. The oxidation proceeds through oxidation from alcohol to aldehyde, in situ imine formation, and final direct oxidation to nitrile.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.