Evidence map›Paper›PMID 30176001›Full record

ArticleJournal of visualized experiments : JoVE2018

Combined Transcranial Magnetic Stimulation and Electroencephalography of the Dorsolateral Prefrontal Cortex.

Pantelis Lioumis, Reza Zomorrodi, Itay Hadas, Zafiris J Daskalakis, Daniel M Blumberger

Abstract readVideo-Audio Media
In one paragraph

Article in Journal of visualized experiments : JoVE, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Pantelis LioumisTemerty Centre for Therapeutic Brain Intervention at the Centre for Addiction and Mental Health; pantelis.lioumis@camh.ca.
Reza ZomorrodiTemerty Centre for Therapeutic Brain Intervention at the Centre for Addiction and Mental Health.
Itay HadasTemerty Centre for Therapeutic Brain Intervention at the Centre for Addiction and Mental Health.
Zafiris J DaskalakisTemerty Centre for Therapeutic Brain Intervention at the Centre for Addiction and Mental Health; Department of Psychiatry and Institute of Medical Science, Faculty of Medicine, University of Toronto.
Daniel M BlumbergerTemerty Centre for Therapeutic Brain Intervention at the Centre for Addiction and Mental Health; Department of Psychiatry and Institute of Medical Science, Faculty of Medicine, University of Toronto.

Funding

Confirmatory Safety and Efficacy Trial of Magnetic Seizure Therapy for DepressionR01MH112815 · NIMH · CENTRE FOR ADDICTION AND MENTAL HEALTH · PI BLUMBERGER, DANIEL M., DASKALAKIS, ZAFIRIS J. · 2017 to 2023
$7.4M
NIMH NIH HHS R01 MH112815
6 · The paper itself

Abstract

Transcranial magnetic stimulation (TMS) is a non-invasive method that produces neural excitation in the cortex by means of brief, time-varying magnetic field pulses. The initiation of cortical activation or its modulation depends on the background activation of the neurons of the cortical region activated, the characteristics of the coil, its position and its orientation with respect to the head. TMS combined with simultaneous electrocephalography (EEG) and neuronavigation (nTMS-EEG) allows for the assessment of cortico-cortical excitability and connectivity in almost all cortical areas in a reproducible manner. This advance makes nTMS-EEG a powerful tool that can accurately assess brain dynamics and neurophysiology in test-retest paradigms that are required for clinical trials. Limitations of this method include artifacts that cover the initial brain reactivity to stimulation. Thus, the process of removing artifacts may also extract valuable information. Moreover, the optimal parameters for dorsolateral prefrontal (DLPFC) stimulation are not fully known and current protocols utilize variations from the motor cortex (M1) stimulation paradigms. However, evolving nTMS-EEG designs hope to address these issues. The protocol presented here introduces some standard practices for assessing neurophysiological functioning from stimulation to the DLPFC that can be applied in patients with treatment resistant psychiatric disorders that receive treatment such as transcranial direct current stimulation (tDCS), repetitive transcranial magnetic stimulation (rTMS), magnetic seizure therapy (MST) or electroconvulsive therapy (ECT).

Indexed as

AdultElectroencephalographyFemaleHumansMalePrefrontal CortexTranscranial Magnetic Stimulation

Identifiers

PMID30176001
PMCPMC6128109

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.