Evidence map›Paper›PMID 30175944›Full record

ArticleNeurological research2018

Temporal lobe contusions on computed tomography are associated with impaired 6-month functional recovery after mild traumatic brain injury: a TRACK-TBI study.

John K Yue, Ethan A Winkler, Ross C Puffer, Hansen Deng, Ryan R L Phelps, Sagar Wagle, Molly Rose Morrissey, Ernesto J Rivera, Sarah J Runyon, Mary J Vassar and 11 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurological research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
  2. A Mouse Model of Temporal Lobe Contusion.Journal of neurotrauma · 2025
    Article
  3. Article
  4. Glibenclamide for Brain Contusions: Contextualizing a Promising Clinical Trial Design that Leverages an Imaging-Based TBI Endotype.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 7 institutions in 2 countries.

John K Yuea Department of Neurological Surgery , University of California San Francisco , San Francisco , CA , USA.ORCID http://orcid.org/0000-0001-9694-7722
Ethan A Winklera Department of Neurological Surgery , University of California San Francisco , San Francisco , CA , USA.
Ross C Pufferc Department of Neurological Surgery , Mayo Clinic , Rochester , MN , USA.
Hansen Denga Department of Neurological Surgery , University of California San Francisco , San Francisco , CA , USA.
Ryan R L Phelpsa Department of Neurological Surgery , University of California San Francisco , San Francisco , CA , USA.
Sagar Waglee Department of Radiology , Mayo Clinic , Rochester , MN , USA.
Molly Rose Morrisseya Department of Neurological Surgery , University of California San Francisco , San Francisco , CA , USA.
Ernesto J Riveraa Department of Neurological Surgery , University of California San Francisco , San Francisco , CA , USA.
Sarah J Runyona Department of Neurological Surgery , University of California San Francisco , San Francisco , CA , USA.
Mary J Vassara Department of Neurological Surgery , University of California San Francisco , San Francisco , CA , USA.
Sabrina R Taylora Department of Neurological Surgery , University of California San Francisco , San Francisco , CA , USA.
Maryse C Cnossenf Department of Public Health , Erasmus Medical Center , Rotterdam , The Netherlands.
Hester F Lingsmaf Department of Public Health , Erasmus Medical Center , Rotterdam , The Netherlands.
Esther L Yuhb Brain and Spinal Injury Center , Zuckerberg San Francisco General Hospital , San Francisco , CA , USA.
Pratik Mukherjeeb Brain and Spinal Injury Center , Zuckerberg San Francisco General Hospital , San Francisco , CA , USA.
David M Schnyerh Department of Psychology , University of Texas at Austin , Austin , TX , USA.ORCID http://orcid.org/0000-0002-7472-2853
Ava M Pucciod Department of Neurological Surgery , University of Pittsburgh Medical Center , Pittsburgh , PA , USA.
Alex B Valadkai Department of Neurological Surgery , Virginia Commonwealth University , Richmond , VA , USA.
David O Okonkwod Department of Neurological Surgery , University of Pittsburgh Medical Center , Pittsburgh , PA , USA.
Geoffrey T Manleya Department of Neurological Surgery , University of California San Francisco , San Francisco , CA , USA.
The Track-Tbi Investigators
San Francisco General Hospital · USErasmus MC · NLUniversity of Pittsburgh Medical Center · USMayo Clinic · USMayo Clinic in Arizona · USThe University of Texas at Austin · USVirginia Commonwealth University · US

Funding

Transforming Research and Clinical Knowledge in Traumatic Brain InjuryU01NS086090 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DIAZ-ARRASTIA, RAMON, GIACINO, JOSEPH THOMAS · 2013 to 2017
$19.1M
Transforming Traumatic Brain Injury Research and Clinical CareRC2NS069409 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MANLEY, GEOFFREY T · 2009 to 2011
$4.3M
NINDS NIH HHS RC2 NS069409NINDS NIH HHS U01 NS086090
6 · The paper itself

Abstract

introductionMild traumatic brain injury (MTBI) can cause persistent functional deficits and healthcare burden. Understanding the association between intracranial contusions and outcome may aid in MTBI treatment and prognosis.

methodsMTBI patients with Glasgow Coma Scale 13-15 and 6-month outcomes [Glasgow Outcome Scale-Extended (GOSE)], without polytrauma from the prospective TRACK-TBI Pilot study were analyzed. Intracranial contusions on computed tomography (CT) were coded by location. Multivariable regression evaluated associations between intracranial injury type (temporal contusion [TC], frontal contusion, extraaxial [epidural/subdural/subarachnoid], other-intraaxial [intracerebral/intraventricular hemorrhage, axonal injury]) and GOSE. Odds ratios (OR) are reported.

resultsOverall, 260 MTBI subjects were aged 44.4 ± 18.1-years; 67.7% were male. Ninety-seven subjects were CT-positive and 46 had contusions (41.3%-frontal, 30.4%-temporal, 21.7%-frontal + temporal, 2.2% each-parietal/occipital/brainstem); 95.7% had concurrent extraaxial hemorrhage. Mortality was 0% at discharge and 2.3% by 6-months. GOSE distribution was 2.3%-death, 1.5%-severe disability, 27.7%-moderate disability, 68.5%-good recovery. Forty-six percent of TC-positive subjects suffered moderate disability or worse (GOSE ≤6) and 41.7% were unable to return to baseline work capacity (RTBWC), compared to 29.1%/20.4% for CT-negative and 26.1%/20.9% for CT-positive subjects without TC. On multivariable regression, TC associated with OR = 3.33 (95% CI [1.16-9.60], p = 0.026) for GOSE ≤6, and OR = 4.48 ([1.49-13.51], p = 0.008) for inability to RTBWC.

conclusionsParenchymal contusions in MTBI are often accompanied by extraaxial hemorrhage. TCs may be associated with 6-month functional impairment. Their presence on imaging should alert the clinician to the need for heightened surveillance of sequelae complicating RTBWC, with low threshold for referral to services.

Indexed as

Recovery of FunctionTomography, X-Ray ComputedAdultBrain ConcussionBrain ContusionFemaleHumansMalePilot ProjectsProspective StudiesTemporal Lobe

Identifiers

PMID30175944
PMCPMC6464373
OpenAlexW2892074141

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.