ArticleJournal of orthopaedic research : official publication of the Orthopaedic Research Society2018
Promoting effective tendon healing and remodeling.
Article in Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- An Ex Vivo Model of Laser-Induced Microdamage to Study Tendon Repair.Tissue engineering. Part A · 2026Article
- Non-Contact, Mechanical Fatigue-Related ACL Injury Prevention Through Extracellular Matrix Crosslink Preservation: A Narrative Review.Journal of functional morphology and kinesiology · 2026Review
- Loadless Tendon Explant Model Exhibits Spontaneous Degradative Phenotypes: AnJournal of clinical medicine research · 2025Article
- Intrinsic Repair Capacity of Resident Tendon Cells is Dependent on Hole Size in an Ex Vivo Model of Laser-Induced Microdamage.bioRxiv : the preprint server for biology · 2025Article
- Tendon mechanobiology in the context of tendon biofabrication.Frontiers in bioengineering and biotechnology · 2025Review
- Article
- Detergent-Free Decellularization Preserves the Mechanical and Biological Integrity of Murine Tendon.Tissue engineering. Part C, Methods · 2022Article
- Altered TGFB1 regulated pathways promote accelerated tendon healing in the superhealer MRL/MpJ mouse.Scientific reports · 2022Article
- Role of the Alarmin S100A9 protein in inducing Achilles tendinopathy in rats.Annals of translational medicine · 2021Article
- MRL/MpJ tendon matrix-derived therapeutic promotes improved healing outcomes in scar-mediated canonical tendon healing.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2021Article
- Tendon Extracellular Matrix Assembly, Maintenance and Dysregulation Throughout Life.Advances in experimental medicine and biology · 2021Review
- Microsurgical reconstruction affects the outcome in a translational mouse model for Achilles tendon healing.Journal of orthopaedic translation · 2020Article
- Innate tissue properties drive improved tendon healing in MRL/MpJ and harness cues that enhance behavior of canonical healing cells.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020Article
- The MRL/MpJ Mouse Strain Is Not Protected From Muscle Atrophy and Weakness After Rotator Cuff Tear.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2020Article
- An Anterior Cruciate Ligament Failure Mechanism.The American journal of sports medicine · 2019Article
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Authors and funding
2 authors.
Funding
Abstract
Daily activities subject our tendons to accumulation of sub-rupture fatigue injury which can lead to tendon rupture. Consequently, tendinopathies account for over 30% of musculoskeletal consultations. We adopted a multidisciplinary approach to determine the role of the extracellular matrix (ECM) in the pathogenesis of tendinopathy and impaired healing of ruptured tendons. We have been investigating three main areas: (i) the pathogenesis of tendon degeneration; (ii) approaches to promoting remodeling of sub-rupture fatigue injuries; and the (iii) role of the ECM in promoting scarless tendon healing. In this Kappa Delta Young Investigator award paper, we describe the key discoveries made in each of our three research areas of focus. Briefly, we discovered that sub-rupture fatigue damage can accumulate from just one bout of fatigue loading. Furthermore, any attempt to repair the fatigue damage diminishes as the severity of induced damage increases. We have utilized exercise to develop animal models of exercise-led degeneration and exercise-led repair of sub-rupture fatigue damage injuries, wherein underlying mechanisms can be uncovered, thereby overcoming a major hurdle to development of therapeutics. Since damage accumulation ultimately leads to rupture that is characterized by formation of a mechanically inferior scar, we have used the MRL/MpJ mouse to evaluate the role of the systemic environment and the local tendon environment in driving regeneration to identify new therapeutic pathways to promote scarless healing. Our data suggests that the therapeutic potential of the MRL/MpJ provisional ECM should be further explored as it may harness biological and structural mechanisms to promote scarless healing. © 2018 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 36:3115-3124, 2018.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.