Evidence map›Paper›PMID 30175684›Full record

ArticleJournal of biological rhythms2018

The Phosphorylation of CREB at Serine 133 Is a Key Event for Circadian Clock Timing and Entrainment in the Suprachiasmatic Nucleus.

Kelin L Wheaton, Katelin F Hansen, Sydney Aten, Kyle A Sullivan, Hyojung Yoon, Kari R Hoyt, Karl Obrietan

Open access · bronzeAbstract read
In one paragraph

Article in Journal of biological rhythms, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.

  1. Systematic review of drugs that modify the circadian system's phase-shifting responses to light exposure.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Kelin L WheatonDivision of Pharmaceutics and Pharmaceutical Chemistry, Ohio State University, Columbus, OH.
Katelin F HansenDepartment of Neuroscience, Ohio State University, Columbus, OH.
Sydney AtenDepartment of Neuroscience, Ohio State University, Columbus, OH.
Kyle A SullivanDepartment of Neuroscience, Ohio State University, Columbus, OH.ORCID 0000-0002-4621-5598
Hyojung YoonDepartment of Neuroscience, Ohio State University, Columbus, OH.ORCID 0000-0002-1376-9527
Kari R HoytDivision of Pharmaceutics and Pharmaceutical Chemistry, Ohio State University, Columbus, OH.
Karl ObrietanDepartment of Neuroscience, Ohio State University, Columbus, OH.ORCID 0000-0002-7525-7121
The Ohio State University · US

Funding

Hippocampal Cellular RhythmsR01MH103361 · NIMH · OHIO STATE UNIVERSITY · PI OBRIETAN, KARL H · 2014 to 2018
$2.0M
Activity-dependent microRNA expression and function in the mature nervous systemR01NS066345 · NINDS · OHIO STATE UNIVERSITY · PI IMPEY, SOREN, OBRIETAN, KARL H · 2010 to 2014
$1.9M
MSK, RSK and the regulation of excitotoxic cell death and structural plasticityR01NS091302 · NINDS · OHIO STATE UNIVERSITY · PI OBRIETAN, KARL H · 2015 to 2018
$1.3M
NIMH NIH HHS R01 MH103361NINDS NIH HHS R01 NS066345NINDS NIH HHS R01 NS091302
6 · The paper itself

Abstract

Within the suprachiasmatic nucleus (SCN)-the locus of the master circadian clock- transcriptional regulation via the CREB/CRE pathway is implicated in the functioning of the molecular clock timing process, and is a key conduit through which photic input entrains the oscillator. One event driving CRE-mediated transcription is the phosphorylation of CREB at serine 133 (Ser

Indexed as

Circadian ClocksAlanineAnimalsCircadian RhythmCyclic AMP Response Element-Binding ProteinGene Knock-In TechniquesMiceMotor ActivityPeriod Circadian ProteinsPhosphorylationSerineSuprachiasmatic Nucleustau ProteinsAlanineCreb1 protein, mouseCyclic AMP Response Element-Binding ProteinPeriod Circadian ProteinsSerinetau Proteinscell synchronyCREBentrainmentsuprachiasmatic nucleustau

Identifiers

PMID30175684
PMCPMC8293705
OpenAlexW2890834442

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.