Evidence map›Paper›PMID 30175525›Full record

ReviewNeuropsychopharmacology reports2018

Utilizing resources of neuropsychopharmacology to address the opioid overdose crisis.

Anthony G Phillips, Michael R Krausz

Abstract readReview
In one paragraph

Review in Neuropsychopharmacology reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Anthony G PhillipsDepartment of Psychiatry, University of British Columbia, Vancouver, British Columbia, Canada.ORCID 0000-0002-4077-5471
Michael R KrauszDepartment of Psychiatry, University of British Columbia, Vancouver, British Columbia, Canada.ORCID 0000-0002-6208-4364

Funding

CIHR
6 · The paper itself

Abstract

backgroundNorth America is facing a severe public health crisis in the form of excessive numbers of deaths due to overdose from self-administration of opioids by individuals who are dependent on these substances.

aimsThere are many factors that must be addressed in order to gain control over this tragedy. Of particular relevance to neuropsychopharmacology is the fact that the problem is due in part to misuse of pharmaceuticals and especially the illicit production of the powerful synthetic opioids, fentanyl, and carfentanil.

methodThe development and adoption of appropriate pharmacotherapies are of critical importance. We discuss specific options to deal effectively with both withdrawal from opioid dependence and substitution of clinically approved drugs in place of illicit substances.

conclusionHopefully, this crisis will reinvigorate both basic and clinical neuropsychopharmacological research leading to the develop new and more effective options for dealing with the many and varied elements of the current opioid crisis as described in the present commentary.

Indexed as

Drug OverdoseHumansNeuropharmacologyOpiate Substitution TreatmentOpioid-Related DisordersPsychopharmacologyUnited Statesbuprenorphinediacetylmorphinehydromorphone, Heantos 4methadone racematenaltrexoneopioid fatal overdoseopioid misuseopioid substitutionopioid withdrawal

Identifiers

PMID30175525
PMCPMC7292312

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.