Evidence map›Paper›PMID 30175407›Full record

ArticleMuscle & nerve2018

Estimating Myofiber Size With Electrical Impedance Myography: a Study In Amyotrophic Lateral Sclerosis MICE.

Kush Kapur, Janice A Nagy, Rebecca S Taylor, Benjamin Sanchez, Seward B Rutkove

2 registry-linked trialsOpen access · greenAbstract read
In one paragraph

Article in Muscle & nerve, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06491732 recruitingnot on this mapstarted 2025, after this paper: background citation

Electrical Impedance Myography Via the Myolex mScan as an ALS Biomarker

TypeobservationalSponsorBeth Israel Deaconess Medical CenterRan2025 to 2027Enrolled80ConditionsAmyotrophic Lateral SclerosisArmsElectrical Impedance Myography
NCT07502989 recruitingnot on this mapstarted 2025, after this paper: background citation

Convenient Quantification of Myopathic Change in Muscle Via Electrical Impedance Myography

Typeobservational_patient_registrySponsorBeth Israel Deaconess Medical CenterRan2025 to 2027Enrolled150ConditionsMyopathy, Muscular Dystrophies, Myositis, Myofibrillar MyopathyArmsElectrical Impedance Myography
3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
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  10. MRI and muscle imaging for idiopathic inflammatory myopathies.Brain pathology (Zurich, Switzerland) · 2021
    Review
  11. Electrical impedance myography: A critical review and outlook.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2021
    Review
  12. Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Electrical Impedance Methods in Neuromuscular Assessment: An Overview.Cold Spring Harbor perspectives in medicine · 2019
    Review
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Kush KapurDepartment of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Janice A NagyDepartment of Neurology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, TCC-810, Boston, Massachusetts, 02215, USA.
Rebecca S TaylorDepartment of Neurology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, TCC-810, Boston, Massachusetts, 02215, USA.
Benjamin SanchezDepartment of Neurology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, TCC-810, Boston, Massachusetts, 02215, USA.ORCID 0000-0002-1594-9847
Seward B RutkoveDepartment of Neurology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, TCC-810, Boston, Massachusetts, 02215, USA.ORCID 0000-0002-6375-3312
Beth Israel Deaconess Medical Center · USBoston Children's Hospital · US

Funding

Next generation electrical impedance myography: the virtual muscle biopsyR01NS091159 · NINDS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI RUTKOVE, SEWARD B. · 2015 to 2019
$1.9M
NIH HHS R01 NS091159NINDS NIH HHS R01 NS091159
6 · The paper itself

Abstract

introductionA method for quantifying myofiber size noninvasively would find wide use, including primary diagnosis and evaluating response to therapy.

methodsUsing prediction algorithms, including the least absolute shrinkage and selection operator, we applied multifrequency electrical impedance myography (EIM) to amyotrophic lateral sclerosis superoxide dismutase 1 G93A mice of different ages and assessed myofiber size histologically.

resultsMultifrequency EIM data provided highly accurate predictions of myofiber size, with a root mean squared error (RMSE) of only 14% in mean myofiber area (corresponding to ± 207 µm DISCUSSION: This impedance-based approach provides predictive variables to assess myofiber size and distribution with good accuracy, particularly in diseases in which myofiber atrophy is the predominant histological feature, without the requirement for biopsy or burdensome quantification. Muscle Nerve 58: 713-717, 2018.

Indexed as

Electric ImpedanceAge FactorsAmyotrophic Lateral SclerosisAnimalsDisease Models, AnimalElectromyographyMiceMice, TransgenicMuscle Fibers, SkeletalMutationSuperoxide DismutaseSOD1 G93A proteinSuperoxide Dismutaseelectrical impedance myographymousemyofiber sizephasepredictionreactanceresistance

Identifiers

PMID30175407
PMCPMC6246784
OpenAlexW2891449781

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.