ArticleIntegrative gynecology and obstetrics journal2018
Utility of Optical Density of Picrosirius Red Birefringence for Analysis of Cross-Linked Collagen in Remodeling of the Peripartum Cervix for Parturition.
Article in Integrative gynecology and obstetrics journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 10 citations in OpenAlex.
- Progesterone regulation of cervix ripening in preterm and term birth in mice.Reproduction (Cambridge, England) · 2025Article
- Multi-parametric quantitative evaluation of murine cervical remodeling during pregnancy and postpartum.Scientific reports · 2025Article
- N,N-dimethylacetamide blocks inflammation-induced preterm birth and remediates maternal systemic immune responses.Scientific reports · 2025Article
- N,N-dimethylacetamide blocks inflammation-induced preterm birth and remediates maternal systemic immune responses.bioRxiv : the preprint server for biology · 2025Article
- Collagen molecular organization preservation in human fascia lata and periosteum after tissue engineering.Frontiers in bioengineering and biotechnology · 2024Article
- Label-free optical imaging of cell function and collagen structure for cell-based therapies.Current opinion in biomedical engineering · 2023Article
- Heterogeneous microstructural changes of the cervix influence cervical funneling.Acta biomaterialia · 2022Article
- Mechanics of cervical remodelling: insights from rodent models of pregnancy.Interface focus · 2019Review
- Photoacoustic imaging of the uterine cervix to assess collagen and water content changes in murine pregnancy.Biomedical optics express · 2019Article
- Cervix Stromal Cells and the Progesterone Receptor A Isoform Mediate Effects of Progesterone for Prepartum Remodeling.Reproductive sciences (Thousand Oaks, Calif.) · 2019Article
- Effects of macrophage depletion on characteristics of cervix remodeling and pregnancy in CD11b-dtr mice.Biology of reproduction · 2019Article
- Immunobiology of Cervix Ripening.Frontiers in immunology · 2019Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
We report on development of a rapid, quantitative analysis technique of collagen fibers in cross-linked structures to assess remodeling of the cervix during the transition from soft to ripening in preparation for birth. Optical density analysis of picrosirius red stain tissue using circular polarized birefringence light from fixed paraffin-embedded or frozen cervix from pregnant mice during phases of remodeling prior to birth. Data were analyzed using NIH Image J and extended recently to include studies of prepartum cervix in peripartum women. Our results, developed a rapid, consistent, technique to quantify cervical organization. This approach assesses the structure of collagen organization (the principle component of the cervix) and is essential for analysis of experimental outcomes that disrupt cervical morphology in rodent models of preterm birth. The technique, in this report has, for the first time permitted rapid, accurate assessment of the stages that define cervical ripening with large numbers of slides from individual animals. The approach integrates analysis of collagen organization, with distensability and inflammation, processes associated with cervical change before birth. This analysis further holds promise to evaluate other tissues, but also fibrolytic and fibrogenic changes in collagen associated with physiological or pathophysiological conditions.
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Registered trials
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