ArticleAnimal nutrition (Zhongguo xu mu shou yi xue hui)2018
Extraction, identification, and antioxidant property evaluation of limonin from pummelo seeds.
Article in Animal nutrition (Zhongguo xu mu shou yi xue hui), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 40 citations in OpenAlex.
- Dynamic succession of the fermentation microbial community and its contribution to aroma in pomelo wine.Food chemistry. Molecular sciences · 2026Article
- Oral Ingestion of Yuzu Seed Oil Suppresses the Development of Atopic Dermatitis-like Skin Lesions in NC/Nga Mice.International journal of molecular sciences · 2024Article
- Identifying citrus limonoids as a potential fusion inhibitor of DENV-2 virus through its in silico study and FTIR analysis.In silico pharmacology · 2024Article
- Natural Products for Acetaminophen-Induced Acute Liver Injury: A Review.Molecules (Basel, Switzerland) · 2023Review
- Rapid diagnosis of COVID-19 using disposal paper capacitive sensor.Analytica chimica acta · 2023Article
- Ultrasound-Assisted Extraction, Chemical Characterization, and Impact on Cell Viability of Food Wastes Derived from Southern Italy Autochthonous Citrus Fruits.Antioxidants (Basel, Switzerland) · 2022Article
- A Green Extraction Method to Achieve the Highest Yield of Limonin and Hesperidin from Lime Peel Powder (Molecules (Basel, Switzerland) · 2022Article
- Recent advances in valorization of citrus fruits processing waste: a way forward towards environmental sustainability.Food science and biotechnology · 2021Review
- Limonin Inhibits IL-1Oxidative medicine and cellular longevity · 2021Article
- Microwave-Assisted Improved Extraction and Purification of Anticancer Nimbolide fromMolecules (Basel, Switzerland) · 2020Article
- The MYB transcription factor CiMYB42 regulates limonoids biosynthesis in citrus.BMC plant biology · 2020Article
- ExploitingToxicology reports · 2020Article
- Limonin: A Review of Its Pharmacology, Toxicity, and Pharmacokinetics.Molecules (Basel, Switzerland) · 2019Review
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Authors and funding
7 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Limonin, the main bioactive phytochemical constituent of limonoids with multi-functions, is enriched in citrus fruits and often found at a high concentration in citrus seeds. The present study was attempted to introduce a new and efficient extraction method to isolate limonoids from pummelo seeds, and to evaluate the antioxidant property of the main constituent limonin in HepG2 cells. Three key single factors were identified for the extraction of limonoids from pummelo seeds using the Box-Behnken experiment design of response surface methodology (RSM), and the optimized extraction parameters were treatment with 89.68 mL of anhydrous acetone for 4.62 h at 78.94 °C, while the yield of limonoids was 11.52 mg/g. The structure of isolated main constituent of the limonoids was further identified as limonin by Fourier transform infrared (FT-IR) spectrometer and nuclear magnetic resonance (NMR) spectrum. Moreover, the molecular data in HepG2 cells revealed that limonin exerted its anti-oxidant property mainly by the activation of nuclear factor (erythroid-2)-like 2 (Nrf2)/kelch-like ECH-associated protein 1 (Keap1)- antioxidant response element (ARE) pathway in the form of transcriptional regulation of
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