Evidence map›Paper›PMID 30175250›Full record

ArticleCommunications biology2018

Nav1.2 haplodeficiency in excitatory neurons causes absence-like seizures in mice.

Ikuo Ogiwara, Hiroyuki Miyamoto, Tetsuya Tatsukawa, Tetsushi Yamagata, Tojo Nakayama, Nafiseh Atapour, Eriko Miura, Emi Mazaki, Sara J Ernst, Dezhi Cao and 9 more

Open access · goldAbstract read
In one paragraph

Article in Communications biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
74citing papers in PubMed, 3 pooled it
9.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

74 citing papers in PubMed, 3 syntheses or guidelines pooled it, 111 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. mTORC2-NaChannels (Austin, Tex.) · 2026
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  7. Review
  8. Frontiers in cellular neuroscience · 2026
    Article
  9. Review
  10. Review
  11. Review
  12. Article
  13. Review
  14. Review
  15. Gene therapies alleviate absence epilepsy associated withbioRxiv : the preprint server for biology · 2025
    Article
  16. Article
  17. DecodingJournal of clinical medicine · 2025
    Review
  18. Article
  19. Review
  20. DecipheringArXiv · 2024
    Article

14 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 8 institutions in 4 countries.

Ikuo OgiwaraLaboratory for Neurogenetics, RIKEN Center for Brain Science, Wako, Saitama, 351-0198, Japan.
Hiroyuki MiyamotoLaboratory for Neurogenetics, RIKEN Center for Brain Science, Wako, Saitama, 351-0198, Japan.ORCID http://orcid.org/0000-0002-5388-8053
Tetsuya TatsukawaLaboratory for Neurogenetics, RIKEN Center for Brain Science, Wako, Saitama, 351-0198, Japan.
Tetsushi YamagataLaboratory for Neurogenetics, RIKEN Center for Brain Science, Wako, Saitama, 351-0198, Japan.
Tojo NakayamaLaboratory for Neurogenetics, RIKEN Center for Brain Science, Wako, Saitama, 351-0198, Japan.
Nafiseh AtapourLaboratory for Neurogenetics, RIKEN Center for Brain Science, Wako, Saitama, 351-0198, Japan.
Eriko MiuraDepartment of Physiology, School of Medicine, Keio University, Tokyo, 160-8582, Japan.
Emi MazakiLaboratory for Neurogenetics, RIKEN Center for Brain Science, Wako, Saitama, 351-0198, Japan.
Sara J ErnstDepartment of Neurology, Baylor College of Medicine, Houston, TX, 77030, USA.
Dezhi CaoNational Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders, Shizuoka, 420-8688, Japan.
Hideyuki OhtaniNational Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders, Shizuoka, 420-8688, Japan.
Shigeyoshi ItoharaLaboratory for Behavioral Genetics, RIKEN Center for Brain Science, Wako, Saitama, 351-0198, Japan.
Yuchio YanagawaDepartment of Genetic and Behavioral Neuroscience, Gunma University Graduate School of Medicine, Maebashi, 371-8511, Japan.
Mauricio MontalSection of Neurobiology, Division of Biological Sciences, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA.ORCID http://orcid.org/0000-0002-0587-946X
Michisuke YuzakiDepartment of Physiology, School of Medicine, Keio University, Tokyo, 160-8582, Japan.
Yushi InoueNational Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders, Shizuoka, 420-8688, Japan.
Takao K HenschLaboratory for Neuronal Circuit Development, RIKEN Center for Brain Science, Wako, Saitama, 351-0198, Japan.ORCID http://orcid.org/0000-0003-0748-8152
Jeffrey L NoebelsDepartment of Neurology, Baylor College of Medicine, Houston, TX, 77030, USA.
Kazuhiro YamakawaLaboratory for Neurogenetics, RIKEN Center for Brain Science, Wako, Saitama, 351-0198, Japan. kazuhiro.yamakawa@riken.jp.
RIKEN Center for Brain Science · JPNational Epilepsy Center · JPBaylor College of Medicine · USBoston Children's Hospital · USKeio University · JPGunma University · JPThe Royal Melbourne Hospital · AUUniversity of California San Diego · US

Funding

Modular Design of Voltage-Gated Channel ProteinsR01GM049711 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MONTAL, MAURICIO S · 1993 to 2017
$4.2M
NIGMS NIH HHS R01 GM049711
6 · The paper itself

Abstract

Mutations in the

Identifiers

PMID30175250
PMCPMC6115194
OpenAlexW2883393209

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.