ArticleWellcome open research2018
Tranexamic acid for significant traumatic brain injury (The CRASH-3 trial): Statistical analysis plan for an international, randomised, double-blind, placebo-controlled trial.
Article in Wellcome open research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 39 citations in OpenAlex.
- Therapeutic efficacy of tranexamic acid on traumatic brain injury: a systematic review and meta-analysis.Scandinavian journal of trauma, resuscitation and emergency medicine · 2024Pooled it
- Efficacy and safety of tranexamic acid in acute traumatic brain injury: a systematic review and meta-analysis of randomized-controlled trials.Intensive care medicine · 2021Pooled it
- Tranexamic acid to reduce head injury death in people with traumatic brain injury: the CRASH-3 international RCT.Health technology assessment (Winchester, England) · 2021Trial
- Tranexamic acid in traumatic brain injury: an explanatory study nested within the CRASH-3 trial.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2021Trial
- Understanding the neuroprotective effect of tranexamic acid: an exploratory analysis of the CRASH-3 randomised trial.Critical care (London, England) · 2020Trial
- Accuracy of time to treatment estimates in the CRASH-3 clinical trial: impact on the trial results.Trials · 2020Trial
- Effects of tranexamic acid on death, disability, vascular occlusive events and other morbidities in patients with acute traumatic brain injury (CRASH-3): a randomised, placebo-controlled trial.Lancet (London, England) · 2019Trial
- Adverse events registration in clinical trial participants with severe acute brain injury: a Delphi consensus study.Acta neurochirurgica · 2025Article
- Effectiveness of road safety interventions: An evidence and gap map.Campbell systematic reviews · 2024Article
- Tranexamic Acid in Non-Traumatic Intracerebral Haemorrhage (TANICH II): Introducing the Potential Role of 3 g Tranexamic Acid in Haematoma Reduction.The Malaysian journal of medical sciences : MJMS · 2023Article
- Efficacy of Tranexamic Acid in the Treatment of Massive Upper Gastrointestinal Bleeding: A Randomized Clinical Trial.Cureus · 2023Article
- Novel blood derived hemostatic agents for bleeding therapy and prophylaxis.Current opinion in hematology · 2022Review
- Efficacy of topicalWorld journal of clinical cases · 2021Article
- Is tranexamic acid going to CRASH the management of traumatic brain injury?Intensive care medicine · 2020Article
- Top ten discoveries of the year: Neurotrauma.Free neuropathology · 2020Article
- Short-term inhibition of fibrinolytic system restores locomotor function after spinal cord injury in mice.Scientific reports · 2019Article
- Prehospital and Emergency Care in Adult Patients with Acute Traumatic Brain Injury.Medical sciences (Basel, Switzerland) · 2019Review
- A nested randomised trial of the effect of tranexamic acid on intracranial haemorrhage and infarction in traumatic brain injury (CRASH-3 trial intracranial bleeding mechanistic study): Statistical analysis plan.Wellcome open research · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 6 institutions in 6 countries.
Funding
Abstract
PubMed holds no abstract for this paper.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.