Evidence map›Paper›PMID 30175245›Full record

ArticleWellcome open research2018

High dose oral and intravenous rifampicin for improved survival from adult tuberculous meningitis: a phase II open-label randomised controlled trial (the RifT study).

Fiona V Cresswell, Kenneth Ssebambulidde, Daniel Grint, Lindsey Te Brake, Abdul Musabire, Rachel R Atherton, Lillian Tugume, Conrad Muzoora, Robert Lukande, Mohammed Lamorde and 4 more

Open access · goldAbstract read
In one paragraph

Article in Wellcome open research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.

  1. Model-Based Meta-analysis of Rifampicin Exposure and Mortality in Indonesian Tuberculous Meningitis Trials.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020
    Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Rifampicin for COVID-19.World journal of virology · 2022
    Review
  8. Article
  9. Rifampicin Can Be Given as Flat-Dosing Instead of Weight-Band Dosing.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020
    Article
  10. Article
  11. Therapeutic advances in neuroinfectious diseases.Therapeutic advances in infectious disease
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 5 countries.

Fiona V CresswellClinical Research Department, London School of Hygiene and Tropical Medicine, London, WC1E 7HT, UK.ORCID https://orcid.org/0000-0002-5070-532X
Kenneth SsebambuliddeClinical Research, Infectious Diseases Institute, Kampala, Uganda.
Daniel GrintTropical Epidemiology Group, London School of Hygiene and Tropical Medicine, London, WC1E 7HT, UK.ORCID https://orcid.org/0000-0001-8001-6544
Lindsey Te BrakeDepartment of Pharmacy, Radboud University Medical Centre, Nijmegan, Netherlands.
Abdul MusabireClinical Research, Infectious Diseases Institute, Kampala, Uganda.
Rachel R AthertonClinical Research, Infectious Diseases Institute, Kampala, Uganda.ORCID https://orcid.org/0000-0003-0952-7557
Lillian TugumeClinical Research, Infectious Diseases Institute, Kampala, Uganda.
Conrad MuzooraMbarara University of Science and Technology, Mbarara, Uganda.
Robert LukandeDepartment of Pathology, College of Health Sciences, Makerere University, Kampala, Uganda.
Mohammed LamordeClinical Research, Infectious Diseases Institute, Kampala, Uganda.
Rob AarnoutseDepartment of Pharmacy, Radboud University Medical Centre, Nijmegan, Netherlands.
David MeyaClinical Research, Infectious Diseases Institute, Kampala, Uganda.
David R Boulware *Clinical Research, Infectious Diseases Institute, Kampala, Uganda.ORCID https://orcid.org/0000-0002-4715-0060
Alison M Elliott *Clinical Research Department, London School of Hygiene and Tropical Medicine, London, WC1E 7HT, UK.ORCID https://orcid.org/0000-0003-2818-9549
Infectious Diseases Institute · UGRadboud University Nijmegen · NLUniversity of London · GBUniversity of Minnesota · USLondon School of Hygiene & Tropical Medicine · GBMakerere University · UGMbarara University of Science and Technology · UG

Funding

Medical Research Council MC_UU_00027/5Medical Research Council MR/K012126/1Wellcome Trust
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

HIVrifampicinTBTBMTuberculous MeningitisUltra

Identifiers

PMID30175245
PMCPMC6113880
OpenAlexW2870543167

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.