Evidence map›Paper›PMID 30175229›Full record

ReviewAlzheimer's & dementia (New York, N. Y.)2018

Neuroscience learning from longitudinal cohort studies of Alzheimer's disease: Lessons for disease-modifying drug programs and an introduction to the Center for Neurodegeneration and Translational Neuroscience.

Justin B Miller, Jeffrey Cummings, Christin Nance, Aaron Ritter

Abstract readReview
In one paragraph

Review in Alzheimer's & dementia (New York, N. Y.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
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  7. Effects of dose change on the success of clinical trials.Contemporary clinical trials communications · 2022
    Article
  8. Article
  9. The roles of executive functioning, simple attention, and medial temporal lobes in early learning, late learning, and delayed recall.Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition · 2022
    Article
  10. Dual Task Performance Is Associated with Amyloidosis in Cognitively Healthy Adults.The journal of prevention of Alzheimer's disease · 2022
    Article
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Justin B MillerCleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, USA.
Jeffrey CummingsCleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, USA.
Christin NanceCleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, USA.
Aaron RitterCleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, USA.

Funding

Renewal of Centers of Biomedical Research Excellence (COBRE) (Phase 2) CNTN - ResubmissionP20GM109025 · NIGMS · CLEVELAND CLINIC FOUNDATION · PI JESSICA KIRKLAND CALDWELL · 2015 to 2026
$22.8M
NIGMS NIH HHS P20 GM109025
6 · The paper itself

Abstract

The development of disease-modifying therapies for Alzheimer's disease is an urgent public health emergency. Recent failures have highlighted the significant challenges faced by drug-development programs. Longitudinal cohort studies are ideal for promoting understanding of this multifactorial, slowly progressive disease. In this section of the special edition, we review several important lessons from longitudinal cohort studies which should be considered in disease-modifying therapy development. In the final section, we introduce the clinical cohort of the Center for Neurodegeneration and Translational Neuroscience. This newly established longitudinal study aims to provide new insights into the neuroimaging and biological marker (biomarkers) correlates of cognitive decline in early Alzheimer's disease and Parkinson's disease (PD).

Indexed as

Alzheimer's diseaseclinical trialsDisease-modifying therapyLongitudinal cohortNeuroscienceParkinson's disease

Identifiers

PMID30175229
PMCPMC6118098

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.