Evidence map›Paper›PMID 30175071›Full record

ArticleFrontiers in oncology2018

Machine Learning Applications in Head and Neck Radiation Oncology: Lessons From Open-Source Radiomics Challenges.

Hesham Elhalawani, Timothy A Lin, Stefania Volpe, Abdallah S R Mohamed, Aubrey L White, James Zafereo, Andrew J Wong, Joel E Berends, Shady AboHashem, Bowman Williams and 38 more

Abstract read
In one paragraph

Article in Frontiers in oncology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. [Contrast-enhanced CT-based habitat radiomics for analyzing the predictive capability for oral squamous cell carcinoma].Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2026
    Article
  3. Review
  4. Review
  5. Review
  6. Article
  7. Article
  8. Review
  9. Review
  10. Improved Prognosis of Treatment Failure in Cervical Cancer with Nontumor PET/CT Radiomics.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2022
    Article
  11. Article
  12. Article
  13. Review
  14. Precision association of lymphatic disease spread with radiation-associated toxicity in oropharyngeal squamous carcinomas.Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology · 2021
    Article
  15. Article
  16. Article
  17. Review
  18. Roadmap: proton therapy physics and biology.Physics in medicine and biology · 2021
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

48 authors.

Hesham ElhalawaniDepartment of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, United States.
Timothy A LinDepartment of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, United States.
Stefania VolpeDepartment of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, United States.
Abdallah S R MohamedDepartment of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, United States.
Aubrey L WhiteDepartment of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, United States.
James ZafereoDepartment of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, United States.
Andrew J WongDepartment of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, United States.
Joel E BerendsDepartment of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, United States.
Shady AboHashemDepartment of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, United States.
Bowman WilliamsDepartment of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, United States.
Jeremy M AymardDepartment of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, United States.
Aasheesh KanwarDepartment of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, United States.
Subha PerniDepartment of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, United States.
Crosby D RockDepartment of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, United States.
Luke CookseyDepartment of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, United States.
Shauna CampbellDepartment of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, United States.
Pei YangDepartment of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, United States.
Khahn NguyenColgate University, Hamilton City, CA, United States.
Rachel B GerGraduate School of Biomedical Sciences, MD Anderson Cancer Center, Houston, TX, United States.
Carlos E CardenasGraduate School of Biomedical Sciences, MD Anderson Cancer Center, Houston, TX, United States.
Xenia J FaveMoores Cancer Center, University of California, La Jolla, San Diego, CA, United States.
Carlo SansoneDipartimento di Ingegneria Elettrica e delle Tecnologie dell'Informazione, Università Degli Studi di Napoli Federico II, Naples, Italy.
Gabriele PiantadosiDipartimento di Ingegneria Elettrica e delle Tecnologie dell'Informazione, Università Degli Studi di Napoli Federico II, Naples, Italy.
Stefano MarroneDipartimento di Ingegneria Elettrica e delle Tecnologie dell'Informazione, Università Degli Studi di Napoli Federico II, Naples, Italy.
Rongjie LiuBaylor College of Medicine, Houston, TX, United States.
Chao HuangBaylor College of Medicine, Houston, TX, United States.
Kaixian YuBaylor College of Medicine, Houston, TX, United States.
Tengfei LiBaylor College of Medicine, Houston, TX, United States.
Yang YuBaylor College of Medicine, Houston, TX, United States.
Youyi ZhangBaylor College of Medicine, Houston, TX, United States.
Hongtu ZhuBaylor College of Medicine, Houston, TX, United States.
Jeffrey S MorrisBaylor College of Medicine, Houston, TX, United States.
Veerabhadran BaladandayuthapaniBaylor College of Medicine, Houston, TX, United States.
John W ShumwayDepartment of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, United States.
Alakonanda GhoshDepartment of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, United States.
Andrei PöhlmannFraunhofer-Institut für Fabrikbetrieb und Automatisierung (IFF), Magdeburg, Germany.
Hady A PhouladyDepartment of Computer Science, University of Southern Maine, Portland, OR, United States.
Vibhas GoyalIndian Institute of Technology Hyderabad, Sangareddy, India.
Guadalupe CanahuateUniversity of Iowa, Iowa City, IA, United States.
G Elisabeta MaraiUniversity of Illinois at Chicago, Chicago, IL, United States.
David VockDepartment of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN, United States.
Stephen Y LaiDepartment of Head and Neck Surgery, University of Texas MD Anderson Cancer Center, Houston, TX, United States.
Dennis S MackinColgate University, Hamilton City, CA, United States.
Laurence E CourtColgate University, Hamilton City, CA, United States.
John FreymannFrederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, MD, United States.
Keyvan FarahaniNational Cancer Institute, Rockville, MD, United States.
Jayashree Kaplathy-CramerDepartment of Radiology and Athinoula A. Martinos Center for Biomedical Imaging, MGH/Harvard Medical School, Boston, MA, United States.
Clifton D FullerDepartment of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, United States.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
Targeting the p53 pathway for reversal of oral premalignancyP50CA097007 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI LEE, HO-YOUNG · 2002 to 2012
$26.1M
Paul Calabresi Clinical Oncology AwardK12CA088084 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI David S. Hong, Scott Kopetz · 2000 to 2026
$14.0M
Informatics Tools for Optimized Imaging Biomarkers for Cancer Research&DiscoveryU24CA180927 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI KALPATHY-CRAMER, JAYASHREE, ROSEN, BRUCE R · 2014 to 2018
$3.4M
Quantitative MRI of Glioblastoma ResponseU01CA154601 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI KALPATHY-CRAMER, JAYASHREE · 2011 to 2016
$3.4M
Using Dynamic Contrast-Enhanced Magnetic Resonance Imaging (DCE-MRI) to Establish Objective Clinical Outcome Measures for Mandibular OsteoradionecrosisR01DE025248 · NIDCR · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI LAI, STEPHEN Y · 2016 to 2020
$2.9M
Uncovering Clinical Evidence in COVID-19 Publications: An Integrated Search via Text & ImagesR01LM012527 · NLM · UNIVERSITY OF DELAWARE · PI EIGENMANN, RUDOLF, MARAI, GEORGETA-ELISABETA · 2017 to 2020
$1.9M
SMART-ACT: Spatial Methodologic Approaches for Risk Assessment and Therapeutic Adaptation in Cancer TreatmentR01CA214825 · NCI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI CANAHUATE, GUADALUPE, FULLER, CLIFTON DAVID · 2017 to 2019
$1.1M
QuBBD: Precision E –Radiomics for Dynamic Big Head & Neck Cancer Data R01CA225190 · NCI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI CANAHUATE, GUADALUPE, FULLER, CLIFTON DAVID · 2017 to 2019
$776k
Using Dynamic Contrast-Enhanced Magnetic Resonance Imaging (DCE-MRI) to Establish Objective Clinical Outcome Measures for Mandibular OsteoradionecrosisR56DE025248 · NIDCR · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI LAI, STEPHEN Y · 2015 to 2015
$470k
NCI NIH HHS K12 CA088084NCI NIH HHS P30 CA008748NCI NIH HHS P50 CA097007NCI NIH HHS R01 CA214825NCI NIH HHS R01 CA225190NCI NIH HHS U01 CA154601NCI NIH HHS U24 CA180927NIDCR NIH HHS R01 DE025248NIDCR NIH HHS R56 DE025248NLM NIH HHS R01 LM012527
6 · The paper itself

Abstract

Radiomics leverages existing image datasets to provide non-visible data extraction via image post-processing, with the aim of identifying prognostic, and predictive imaging features at a sub-region of interest level. However, the application of radiomics is hampered by several challenges such as lack of image acquisition/analysis method standardization, impeding generalizability. As of yet, radiomics remains intriguing, but not clinically validated. We aimed to test the feasibility of a non-custom-constructed platform for disseminating existing large, standardized databases across institutions for promoting radiomics studies. Hence, University of Texas MD Anderson Cancer Center organized two public radiomics challenges in head and neck radiation oncology domain. This was done in conjunction with MICCAI 2016 satellite symposium using Kaggle-in-Class, a machine-learning and predictive analytics platform. We drew on clinical data matched to radiomics data derived from diagnostic contrast-enhanced computed tomography (CECT) images in a dataset of 315 patients with oropharyngeal cancer. Contestants were tasked to develop models for (i) classifying patients according to their human papillomavirus status, or (ii) predicting local tumor recurrence, following radiotherapy. Data were split into training, and test sets. Seventeen teams from various professional domains participated in one or both of the challenges. This review paper was based on the contestants' feedback; provided by 8 contestants only (47%). Six contestants (75%) incorporated extracted radiomics features into their predictive model building, either alone (

Indexed as

big datahead and neckmachine learningradiation oncologyradiomics challenge

Identifiers

PMID30175071
PMCPMC6107800

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.