ArticleGland surgery2018
The use of tranexamic acid in microsurgery-is it safe?
Article in Gland surgery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Impact of Tranexamic Acid in Breast Plastic Surgery: A Systematic Review and Meta-Analysis.Aesthetic plastic surgery · 2026Pooled it
- Perioperative tranexamic acid in abdominally based free-flap breast reconstruction: A single-surgeon retrospective series.JPRAS open · 2026Article
- Mythbusters in Microsurgery: Evaluating Evidence and Debunking Dogma-A Practical Review: Part II.Plastic and reconstructive surgery. Global open · 2026Review
- Use of Tranexamic Acid in Head and Neck Free Flap Reconstruction.Microsurgery · 2025Article
- The Effects of Systemic Tranexamic Acid Administration on Drainage Volume, Length of Hospital Stay, and Postoperative Complications in Reduction Mammaplasty.Journal of clinical medicine · 2024Article
- The Effects of Systemic Tranexamic Acid Administration on Drainage Volume, Duration of Drain Placement, and Length of Hospital Stay in Skin- and Nipple-Sparing Mastectomies with Immediate Expander-Based Breast Reconstruction.Journal of clinical medicine · 2024Article
- Topical Tranexamic Acid (TXA) Decreases Time to Drain Removal, Wound Healing Complications, and Postoperative Blood Loss in Autologous Breast Reconstruction: A Retrospective Study.Plastic surgery (Oakville, Ont.) · 2024Article
- Temperance With Tranexamic Acid: Increased Risk of Venous Thromboembolism in Abdominoplasty.Aesthetic surgery journal. Open forum · 2024Article
- Successful reconstruction of an ankle defect with free tissue transfer in a hemophilia A patient with repetitive hemoarthrosis: A case report.World journal of clinical cases · 2023Article
- The Usage of Intravenous Tranexamic Acid in Reduction Mammaplasty Safely Reduces Hematoma Rates.Annals of plastic surgery · 2023Article
- The effect of tranexamic acid on blood loss in liposuction: a randomized controlled study.European journal of plastic surgery · 2023Article
- Comparing complications and perioperative teams in microsurgical breast reconstruction: retrospective cohort study.Gland surgery · 2022Article
- A Systematic Review of Tranexamic Acid in Plastic Surgery: What's New?Plastic and reconstructive surgery. Global open · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAn appropriate and adequate blood flow and oxygen delivery is paramount to free flap viability and success. The perioperative use of tranexamic acid (TXA) is associated with less risk for blood loss and blood transfusion in trauma, gynaecology, ear nose and throat (ENT) and orthopaedic surgery. As an antifibrinolytic drug, TXA has generally been avoided in microsurgery. The aim of this study is to evaluate the safety and benefit of using TXA in microsurgery.
methodsWe performed a retrospective single centre cohort study at the Pyramid Clinic, Zurich, Switzerland, including 98 free tissue transfers for breast reconstruction from 2011 to 2013. According to the estimated blood loss, up to 3 g TXA were administered intravenously in 63 free flaps perioperatively.
resultsNo thrombosis (0%) of micro-anastomosis and 5 haematomas (10.0%) occurred after administration of TXA. In the control group, 1 thrombosis (3.0%) of a flap-vein and 6 haematomas (18.2%) occurred. Blood loss was significant lower (P<0.001) after administration of TXA.
conclusionsIn this study, administration of TXA did not increase thrombosis in free tissue transfer and showed a reduced haematoma rate and significant reduction of blood loss. TXA is supposed to be safe and a reasonable adjunct for patients with anaemia and a higher intraoperative or postoperative blood loss.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.