ReviewGland surgery2018
Breast cancer-related lymphedema: risk factors, precautionary measures, and treatments.
Review in Gland surgery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 159 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of a Manual Therapy Program to Reduce the Evolution Time of Axillary Web Syndrome
Lymphaticovenous Anastomosis as a Surgical Treatment for Breast Cancer-Related Lymphedema
Who cites it
159 citing papers in PubMed, 6 syntheses or guidelines pooled it, 333 citations in OpenAlex.
- Preventing Secondary Lymphedema: A Systematic Review and Meta-Analysis on the Efficacy of Immediate Lymphovenous Anastomosis.Journal of surgical oncology · 2025Pooled it
- Efficacy of Immediate Lymphatic Reconstruction in Prevention of Breast Cancer-Related Lymphedema: A Systematic Review and Meta-Analysis.Microsurgery · 2025Pooled it
- Wrapping up the evidence: bandaging in breast cancer-related lymphedema-a systematic review and meta-analysis.Breast cancer (Tokyo, Japan) · 2025Pooled it
- Risk Factors for Breast Cancer-Related Lymphedema: An Umbrella Review.Annals of surgical oncology · 2024Pooled it
- Risk factors for long-term arm morbidities following breast cancer treatments: A systematic review.Oncotarget · 2023Pooled it
- Effectiveness of physical therapy in axillary web syndrome after breast cancer: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023Pooled it
- The 6 month interim analysis of a randomized controlled trial assessing the quality of life in patients with breast cancer related lymphedema undergoing lymphaticovenous anastomosis vs. conservative therapy.Scientific reports · 2024Trial
- The effect of myofascial release in patients with breast cancer-related lymphedema: a cross-over randomized controlled trial.European journal of physical and rehabilitation medicine · 2023Trial
- Trial
- Effects of Tuina Combined With Moxibustion on Breast Cancer-Related Lymphedema: A Randomized Cross-Over Controlled Trial.Integrative cancer therapiesTrial
- Targeted LVA guided by ultra-high frequency ultrasound and ICG lymphography: A pilot study.JPRAS open · 2026Article
- A dermal backflow atlas of lymphatic dysfunction in breast cancer-related lymphedema with machine learning-based stage prediction.Breast cancer research and treatment · 2026Article
- Simplified LYMPHA for Prevention of Breast Cancer-Related Lymphedema After Axillary Dissection: Initial Feasibility Experience from South Asia.European journal of breast health · 2026Article
- [Ipsilateral venous puncture and catheter placement after axillary lymphadenectomy].Die Anaesthesiologie · 2026Review
- Receipt of Combined Axillary Dissection and Nodal Irradiation Varies by Age.Annals of surgical oncology · 2026Article
- Predicting sentinel lymph node metastasis in breast cancer using an interpretable machine learning approach based on multi-domain clinical features.Breast cancer research : BCR · 2026Article
- Superficial and Functional Imaging of the Posterior Upper Arm Pathway in the Healthy Population.Journal of surgical oncology · 2026Article
- Radiation induces senescence in lymphatic endothelial cells (LECs) and murine tail lymphedema tissue, contributing to lymphedema progression.Cell death & disease · 2026Article
- Confronting clinical tradition: ipsilateral arm use after breast cancer surgery in Japan.Journal of anesthesia · 2026Review
- Patient preferences for managing chronic breast cancer-related lymphedema in China: evidence from a discrete choice experiment.BMC health services research · 2026Article
99 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Breast cancer-related lymphedema (BCRL) is a negative sequela of breast cancer treatment, and well-established risk factors include axillary lymph node dissection (ALND) and regional lymph node radiation (RLNR). BCRL affects approximately 1 in 5 patients treated for breast cancer, and it has a significant negative impact on patients' quality of life after breast cancer treatment, serving as a reminder of previous illness. This paper is a comprehensive review of the current evidence regarding BCRL risk factors, precautionary guidelines, prospective screening, early intervention, and surgical and non-surgical treatment techniques. Through establishing evidence-based BCRL risk factors, researchers and clinicians are better able to prevent, anticipate, and provide early intervention for BCRL. Clinicians can identify patients at high risk and utilize prospective screening programs, which incorporate objective measurements, patient reported outcome measures (PROM), and clinical examination, thereby creating opportunities for early intervention and, accordingly, improving BCRL prognosis. Innovative surgical techniques that minimize and/or prophylactically correct lymphatic disruption, such as axillary reverse mapping (ARM) and lymphatic-venous anastomoses (LVAs), are promising avenues for reducing BCRL incidence. Nonetheless, for those patients with BCRL who remain unresponsive to conservative methods like complete decongestive therapy (CDT), surgical treatment options aiming to reduce limb volume or restore lymphatic flow may prove to be palliative or corrective. It is only through a strong team-based approach that such a continuum of care can exist, and a multidisciplinary approach to BCRL screening, intervention, and research is therefore strongly encouraged.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.