ArticleJournal of thoracic disease2018
Viral infection in community acquired pneumonia patients with fever: a prospective observational study.
Article in Journal of thoracic disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 60 citations in OpenAlex.
- Viral non-SARS-CoV-2 etiology of community-acquired pneumonia (CAP) in Southeast Asia: a review and pooled analysis.IJID regions · 2025Review
- The correlation between inflammatory markers and postoperative pulmonary infection in patients with aneurysmal subarachnoid hemorrhage and the construction of prediction model.Frontiers in neurology · 2025Article
- Association between lactate dehydrogenase and ventilator-associated pneumonia risk: an analysis of the MIMIC database 2001-2019.BMC pulmonary medicine · 2024Article
- Multivariable Risk Modelling and Survival Analysis with Machine Learning in SARS-CoV-2 Infection.Journal of clinical medicine · 2023Article
- The risk factors involved in airway mucus plug in children with ADV Pneumonia.BMC pulmonary medicine · 2023Article
- Evaluation of the effect of Remdesivir on some biomarkers in Iraqi patients with coronavirus 2019 (COVID-19): A cross-sectional study.Journal of medicine and life · 2023Article
- Comparative Genomic Analysis of Warthog and Sus Scrofa Identifies Adaptive Genes Associated with African Swine Fever.Biology · 2023Article
- Study on the Changes and Significance of Immune State and Cycokines in Children with Adenovirus Pneumonia.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- LDH, CRP and ALB predict nucleic acid turn negative within 14 days in symptomatic patients with COVID-19.Scottish medical journal · 2021Article
- Nomogram based on albumin and neutrophil-to-lymphocyte ratio for predicting postoperative complications after pancreaticoduodenectomy.Gland surgery · 2021Article
- Clinical manifestation, laboratory and radiology finding, treatment and outcomes of COVID-19: A systematic review and meta-analysis.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2021Review
- High serum lactate dehydrogenase and dyspnea: Positive predictors of adverse outcome in critical COVID-19 patients in Yichang.World journal of clinical cases · 2020Article
- Mortality Rate and Predictors of Mortality in Hospitalized COVID-19 Patients with Diabetes.Healthcare (Basel, Switzerland) · 2020Article
- Lactate dehydrogenase levels predict coronavirus disease 2019 (COVID-19) severity and mortality: A pooled analysis.The American journal of emergency medicine · 2020Review
- Prognostic value of lactate dehydrogenase for in-hospital mortality in severe and critically ill patients with COVID-19.International journal of medical sciences · 2020Article
- Lung ultrasonography versus chest radiography for the diagnosis of pediatric community acquired pneumonia in emergency department: a meta-analysis.Journal of thoracic disease · 2019Article
- Observational
Corrections and comments
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Authors and funding
19 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPatients with community acquired pneumonia (CAP) caused by viruses can develop severe complications, which result in hospitalization and death. The purpose of this study was to analyse the aetiology, incidence, clinical characteristics, and outcomes of CAP patients with fever during non-pandemics, and then to provide theoretical basis for accurate diagnosis and treatment in CAP patients.
methodsAn enrolment system was established for monitoring the CAP patients with fever. Multiplex polymerase chain reaction (mPCR) kits were used to detect 10 viruses [influenza A and B, adenovirus (ADV), respiratory syncytial virus (RSV) A and B, picornavirus, parainfluenza virus (PIV), coronavirus, human metapneumovirus (HMPV), and bocavirus]. Data on age, gender, underlying diseases, complications, laboratory indexes, and outcomes were collected by physicians.
resultsThis prospective study included 320 patients with fever. Among them, 23.4% were viral-positive by mPCR, with influenza virus most prominent followed by picornavirus. Strong variation in seasonal distribution was shown in viral infections, with peak months from December to February. Patients with influenza infection were likely to be taken to emergency rooms and have respiratory failure with higher creatinine kinase levels and lower white blood cell counts. Streptococcus pneumoniae followed by haemophilus influenzae were the most common bacteria in viral co-infections, which accounted for one third of virus-positive patients. Viral CAP and mixed CAP were not independent factors for death. In addition, lactate dehydrogenase (LDH) >246 IU/L [odds ratio (OR) =7.06, 95% confidence interval (CI): 2.15-23.2, P=0.001], and serum calcium <2.18 mmol/L (OR =6.67, 95% CI: 1.42-31.3, P=0.016) were associated with death.
conclusionsViruses play an important role in CAP patients with fever, a systematic clinical, radiological and biological analysis of these patients can contribute to effective therapy that may prevent the development of CAP and improve the outcomes. The present work showed an elaborate analysis evidence of viral infection among fever CAP inpatients.
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