Evidence map›Paper›PMID 30174873›Full record

ArticleJournal of thoracic disease2018

Lung ultrasound as a monitoring tool in lung transplantation in rodents: a feasibility study.

Paolo Diana, Davide Zampieri, Elisa Furlani, Emanuele Pivetta, Fiorella Calabrese, Federica Pezzuto, Giuseppe Marulli, Federico Rea, Carlo Ori, Paolo Persona

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of thoracic disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Paolo DianaDepartment of Medicine, Thoracic and Vascular Sciences, University of Padova, Padova, Italy.
Davide ZampieriDepartment of Cardiac, Thoracic and Vascular Sciences, University of Padova, Padova, Italy.
Elisa FurlaniDepartment of Medicine, Thoracic and Vascular Sciences, University of Padova, Padova, Italy.
Emanuele PivettaDepartment of Medical Sciences, University of Turin, Torino, Italy.
Fiorella CalabreseDepartment of Cardiac, Thoracic and Vascular Sciences, University of Padova, Padova, Italy.
Federica PezzutoDepartment of Cardiac, Thoracic and Vascular Sciences, University of Padova, Padova, Italy.
Giuseppe MarulliDepartment of Cardiac, Thoracic and Vascular Sciences, University of Padova, Padova, Italy.
Federico ReaDepartment of Cardiac, Thoracic and Vascular Sciences, University of Padova, Padova, Italy.
Carlo OriDepartment of Medicine, Thoracic and Vascular Sciences, University of Padova, Padova, Italy.
Paolo PersonaDepartment of Emergency, Azienda Ospedaliera di Padova, Padova, Italy.
University of Padua · ITAzienda Ospedaliera di Padova · ITUniversity of Turin · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOrthotopic lung transplantation in rats has been developed as a model to study organ dysfunction, but available tools for monitoring the graft function are limited. In this study, lung ultrasound (LUS) is proposed as a new non-invasive monitoring tool in awake rodents.

methodsLUS was applied to native and graft lung of six rats after left orthotopic transplantation. Rats were monitored with LUS while awake, patterns identified, images evaluated with a scoring system, intra- and inter-rater agreement was assessed and examination times analyzed.

resultsA total of 78 clips were recorded. The median quality score of LUS was 3.66/4 for left hemithorax and 3.71/4 for native right side. The intra-rater agreement was 0.53 and 0.65 and the inter-rater agreement was 0.61 (P<0.01). Median time to complete the examination was 233.0 seconds (IQR 142) for both lungs, lowered from 254.0 seconds (IQR 129.5) (first trimester of study) to 205.5 seconds (IQR 88.5) (second trimester of the study). Significant findings on LUS were confirmed on pathological examination.

conclusionsLUS in awake rodents without shaving has been shown to be both feasible and safe and the images collected were of good quality and comparable to those obtained in anesthetized rats without bristles.

Indexed as

animalgraft rejectionModelspostoperative complicationstransplantultrasonography

Identifiers

PMID30174873
PMCPMC6106042
OpenAlexW2845833125

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.