ArticleFrontiers in neurology2018
Ictal Mammalian Dive Response: A Likely Cause of Sudden Unexpected Death in Epilepsy.
Article in Frontiers in neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 36 citations in OpenAlex.
- Review
- High density probes reveal medullary seizure and rapid medullary shutdown in a model of fatal apnea in seizure.Epilepsy research · 2025Article
- Carotid body stimulation as a potential intervention in sudden death in epilepsy.Epilepsy & behavior : E&B · 2022Article
- Diaphragmatic pacing for the prevention of sudden unexpected death in epilepsy.Brain communications · 2022Article
- Hiding in plain sight? A review of post-convulsive leukocyte elevations.Frontiers in neurology · 2022Review
- Utilizing multimodal imaging to visualize potential mechanism for sudden death in epilepsy.Epilepsy & behavior : E&B · 2021Article
- Ictal activation of oxygen-conserving reflexes as a mechanism for sudden death in epilepsy.Epilepsia · 2021Article
- The Good, the Bad, and the Deadly: Adenosinergic Mechanisms Underlying Sudden Unexpected Death in Epilepsy.Frontiers in neuroscience · 2021Review
- Mechanisms and prevention of acid reflux induced laryngospasm in seizing rats.Epilepsy & behavior : E&B · 2020Article
- Directed Connectivity Analysis of the Neuro-Cardio- and Respiratory Systems Reveals Novel Biomarkers of Susceptibility to SUDEP.IEEE open journal of engineering in medicine and biology · 2020Article
- The Mammalian Diving Response: Inroads to Its Neural Control.Frontiers in neuroscience · 2020Review
- Let's talk SUDEP.Noro psikiyatri arsivi · 2019Review
- Sudden Unexpected Death and the Mammalian Dive Response: Catastrophic Failure of a Complex Tightly Coupled System.Frontiers in physiology · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Even though sudden unexpected death in epilepsy (SUDEP) takes the lives of thousands of otherwise healthy epilepsy patients every year, the physiopathology associated with this condition remains unexplained. This article explores important parallels, which exist between the clinical observations and pathological responses associated with SUDEP, and the pathological responses that can develop when a set of autonomic reflexes known as the mammalian dive response (MDR) is deployed. Mostly unknown to physicians, this evolutionarily conserved physiological response to prolonged apnea economizes oxygen for preferential use by the brain. However, the drastic cardiovascular adjustments required for its execution, which include severe bradycardia and the sequestration of a significant portion of the total blood volume inside the cardiopulmonary vasculature, can result in many of the same pathological responses associated with SUDEP. Thus, this article advances the hypothesis that prolonged apneic generalized tonic clonic seizures induce augmented forms of the MDR, which, in the most severe cases, cause SUDEP.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.