ArticleFrontiers in physiology2018
Cerebrovascular Reactivity and Central Arterial Stiffness in Habitually Exercising Healthy Adults.
Article in Frontiers in physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Role of Shear Stress in the Cerebrovascular Response to Acute Exercise
Autonomic Dysfunction, Brain Blood Flow and Cognitive Decline in Veterans With Gulf War Illness
The Impact of Cerebral Anatomical Variations on Cerebrovascular Reactivity
Who cites it
32 citing papers in PubMed, 40 citations in OpenAlex.
- Association between cardiorespiratory fitness and cerebrovascular reactivity to a breath-hold stimulus in older adults: influence of aerobic exercise training.Journal of applied physiology (Bethesda, Md. : 1985) · 2022Trial
- Can exercise training enhance the repeated remote ischaemic preconditioning stimulus on peripheral and cerebrovascular function in high-risk individuals?European journal of applied physiology · 2021Trial
- Article
- Shear-mediated dilation of the internal carotid artery is attenuated under hypocapnic conditions beyond reductions in shear stimulus.European journal of applied physiology · 2026Article
- An acute concurrent exercise bout better preserves cerebrovascular reactivity to hypocapnia than either resistance or aerobic exercise.European journal of applied physiology · 2026Article
- Sex differences in cerebral pulsatility and damping: A 4D flow MRI study.Experimental physiology · 2026Article
- Article
- Observational
- Lower diastolic velocity in the internal carotid artery mediates lower cerebral blood flow with age.Journal of applied physiology (Bethesda, Md. : 1985) · 2025Article
- Oxidative stress suppresses internal carotid artery dilation to hypercapnia in healthy older adults.Journal of applied physiology (Bethesda, Md. : 1985) · 2025Article
- Exercise-mediated cerebrovascular repair in Alzheimer's disease: from pathophysiology to therapeutic precision.Frontiers in aging neuroscience · 2025Review
- Impact of arterial stiffness on cerebrovascular function: a review of evidence from humans and preclincal models.American journal of physiology. Heart and circulatory physiology · 2024Review
- Association between serum prostacyclin and cerebrovascular reactivity in healthy young and older adults.Experimental physiology · 2023Article
- Neurocirculatory regulation and adaptations to exercise in chronic kidney disease.American journal of physiology. Heart and circulatory physiology · 2023Review
- Cerebral hemodynamics comparison using transcranial doppler ultrasound and 4D flow MRI.Frontiers in physiology · 2023Article
- The Utility of High Intensity Interval Training to Improve Cognitive Aging in Heart Disease Patients.International journal of environmental research and public health · 2022Review
- The relationships between age, sex, and cerebrovascular reactivity to hypercapnia using traditional and kinetic-based analyses in healthy adults.American journal of physiology. Heart and circulatory physiology · 2022Article
- Sex-specific effects of cardiorespiratory fitness on age-related differences in cerebral hemodynamics.Journal of applied physiology (Bethesda, Md. : 1985) · 2022Article
- Daily-Life Physical Activity of Healthy Young Adults Associates With Function and Structure of the Hippocampus.Frontiers in human neuroscience · 2022Article
- Proceedings from the Albert Charitable Trust Inaugural Workshop on 'Understanding the Acute Effects of Exercise on the Brain'.Brain plasticity (Amsterdam, Netherlands) · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Reduced cerebrovascular reactivity to a vasoactive stimulus is associated with age-related diseases such as stroke and cognitive decline. Habitual exercise is protective against cognitive decline and is associated with reduced stiffness of the large central arteries that perfuse the brain. In this context, we evaluated the age-related differences in cerebrovascular reactivity in healthy adults who habitually exercise. In addition, we sought to determine the association between central arterial stiffness and cerebrovascular reactivity. We recruited 22 young (YA: age = 27 ± 5 years, range 18-35 years) and 21 older (OA: age = 60 ± 4 years, range 56-68 years) habitual exercisers who partake in at least 150 min of structured aerobic exercise each week. Middle cerebral artery velocity (MCAv) was recorded using transcranial Doppler ultrasound. In order to assess cerebrovascular reactivity, MCAv, end-tidal carbon dioxide (ETCO
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.