Evidence map›Paper›PMID 30174594›Full record

ArticleFrontiers in behavioral neuroscience2018

Interictal Abnormalities of Neuromagnetic Gamma Oscillations in Migraine Following Negative Emotional Stimulation.

Ting Wu, Jie Fan, Yueqiu Chen, Jing Xiang, Donglin Zhu, Junpeng Zhang, Jingping Shi, Tianzi Jiang

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in behavioral neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00600717 (Localizing Functional Brain Cortices and Epileptogenic Zones With High Frequency Brain Signals), which is not on this map. Cited by 4 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 2 pooled it
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00600717 withdrawnnot on this map

Localizing Functional Brain Cortices and Epileptogenic Zones With High Frequency Brain Signals

TypeobservationalSponsorChildren's Hospital Medical Center, CincinnatiRan2000 to 2027Enrolled0ConditionsEpilepsy, Migraine, Headache, Pain
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 2 syntheses or guidelines pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Ting WuDepartment of Neurology, Nanjing Brain Hospital, Nanjing Medical University, Nanjing, China.
Jie FanDepartment of Neurology, Nanjing Brain Hospital, Nanjing Medical University, Nanjing, China.
Yueqiu ChenDepartment of Neurology, Nanjing Brain Hospital, Nanjing Medical University, Nanjing, China.
Jing XiangDepartment of Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States.
Donglin ZhuDepartment of Neurology, Nanjing Brain Hospital, Nanjing Medical University, Nanjing, China.
Junpeng ZhangDepartment of Medical Information and Engineering, School of Electrical Engineering and Information, Sichuan University, Chengdu, China.
Jingping ShiDepartment of Neurology, Nanjing Brain Hospital, Nanjing Medical University, Nanjing, China.
Tianzi JiangKey Laboratory for NeuroInformation of the Ministry of Education, School of Life Sciences and Technology, University of Electronic Science and Technology of China, Chengdu, China.
Nanjing Brain Hospital · CNNanjing Medical University · CNChengdu University of Information Technology · CNCincinnati Children's Hospital Medical Center · USUniversity of Electronic Science and Technology of China · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Here, we aimed to investigate brain activity in migraineurs in response to emotional stimulation. Magnetoencephalography (MEG) was used to examine 20 patients with episodic migraine (EM group), 15 patients with chronic migraine (CM group), and 35 healthy participants (control group). Neuromagnetic brain activity was elicited by emotional stimulation using photographs of facial expressions. We analyzed the latency and amplitude of M100 and M170 components and used Morlet wavelet and beamformers to analyze the spectral and spatial signatures of MEG signals in gamma band (30-100 Hz). We found that the timing and frequency of MEG activity differed across the three groups in response negative emotional stimuli. First, peak M170 amplitude was significantly lower in the CM group than in the control group. Second, compared with the control group, the average spectral power was significantly lower in the EM group and CM group at M100 and M170. Third, the average spectral powers of the M100 and M170 in the CM group were negatively correlated with either HAM-D scores or migraine attack frequency. No significant differences across groups was found for positive or neutral emotional stimuli. Furthermore, after negative emotional stimuli, the MEG source analysis demonstrated that the CM group showed a significantly higher percentage of amygdala activation than the control group for M100 and M170. Thus, during headache free phases, migraineurs have abnormal brain activity in the gamma band in response to negative emotional stimuli.

Indexed as

emotional stimulationgamma oscillationM100M170magnetoencephalographymigraine

Identifiers

PMID30174594
PMCPMC6108251
OpenAlexW2887192514

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.