ArticleClinical epidemiology2018
Development and validation of risk score to estimate 1-year late poststroke epilepsy risk in ischemic stroke patients.
Article in Clinical epidemiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Incidence and risk factors of post-stroke seizures and epilepsy: systematic review and meta-analysis.The Journal of international medical research · 2023Pooled it
- Association of atherogenic index of plasma and post-stroke epilepsy in patients with ischemic stroke: a multicenter retrospective study in China.Therapeutic advances in neurological disorders · 2026Article
- Differences in patterns of outpatient epilepsy-specific medication initiation after acute ischemic stroke in the Medicare population.Epilepsia · 2025Observational
- An automatic deep-learning approach for the prediction of post-stroke epilepsy after an initial intracerebral hemorrhage based on non-contrast computed tomography imaging.Quantitative imaging in medicine and surgery · 2025Article
- Pathophysiology, Diagnosis, Prognosis, and Prevention of Poststroke Epilepsy: Clinical and Research Implications.Neurology · 2024Review
- The Association of Epileptic Seizures after Acute Ischemic Stroke with Cerebral Cortical Involvement and Electroencephalographic Changes.Medicina (Kaunas, Lithuania) · 2024Article
- The Primary Prevention of Poststroke Epilepsy in Patients With Middle Cerebral Artery Infarct: Protocol for a Randomized Controlled Trial.JMIR research protocols · 2023Article
- Post-stroke seizures, epilepsy, and mortality in a prospective hospital-based study.Frontiers in neurology · 2023Article
- Risk Factors Associated with Epilepsy Related to Cerebrovascular Disease: A Systematic Review and Meta-Analysis.Neuropsychiatric disease and treatment · 2023Review
- Application of Machine Learning Methods for Epilepsy Risk Ranking in Patients with Hematopoietic Malignancies Using.Journal of personalized medicine · 2022Article
- Asymmetric distribution of enlarged perivascular spaces in centrum semiovale may be associated with epilepsy after acute ischemic stroke.CNS neuroscience & therapeutics · 2022Article
- Risk of Incident Epilepsy After a Middle Cerebral Artery Territory Infarction.Frontiers in neurology · 2022Article
- Hospital Revisits for Post-Ischemic Stroke Epilepsy after Acute Stroke Interventions.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2022Article
- Risk factors for seizures after intracerebral hemorrhage: Ethnic/Racial Variations of Intracerebral Hemorrhage (ERICH) Study.Clinical neurology and neurosurgery · 2020Article
- Subsequent Development of Epithelial Ovarian Cancer After Ovarian Surgery for Benign Ovarian Tumor: A Population-Based Cohort Study.Clinical epidemiology · 2020Article
- The progress in predictive modeling of post-stroke epilepsy.Frontiers in neurologyReview
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study aimed to develop and validate a prognostic model for the 1-year risk of late poststroke epilepsy (PSE). MATERIALS AND
methodsWe included patients initially diagnosed with ischemic stroke between 2003 and 2014 in a National Health Insurance claims-based cohort in Taiwan. Patients were further divided into development and validation cohorts based on their year of stroke diagnosis. Multivariable Cox regression with backward elimination was used to analyze the association between 1-year PSE and risk factors before and on stroke admission.
resultsIn total, 1,684 (1.93%) and 725 (1.87%) ischemic stroke patients comprising the development and validation cohorts, respectively, experienced late PSE within 1 year after stroke. Seven clinical variables were examined to be independently associated with 1-year risk of PSE. We developed a risk score called "PSEiCARe" ranging from 0 to 16 points, comprising the following factors: prolonged hospital stay (>2 weeks, 1 point), seizure on admission (6 points), elderly patients (age ≥80 years, 1 point), intensive care unit stay on admission (3 points), cognitive impairment (dementia, 2 points), atrial fibrillation (2 points), and respiratory tract infection (pneumonia) on admission (1 point). Patients were further classified into low-, medium-, high-, and very-high-risk groups. The incidence (per 100 person-years) was 0.64 (95% CI: 0.56-0.71) for the low-risk, 2.62 (95% CI: 2.43-2.82) for the medium-risk, 10.3 (95% CI: 9.48-11.3) for the high-risk, and 28.2 (95% CI: 24.0-33.0) for the very-high-risk groups. Discrimination and calibration were satisfactory, with a Harrell's
conclusionPSEiCARe is an easy-to-use prognostic score that integrates patient characteristics and clinical factors on stroke admission to predict 1-year PSE risk; it has the potential to assist individualized patient management and improve clinical practice, thereby preventing the occurrence of late PSE.
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