ReviewDiabetes, metabolic syndrome and obesity : targets and therapy2018
Medications that cause weight gain and alternatives in Canada: a narrative review.
Review in Diabetes, metabolic syndrome and obesity : targets and therapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Weight Changes With Tirzepatide and Concomitant Weight-Inducing Medications: Post Hoc Analysis of Randomized Clinical Trials.JAMA network open · 2026Pooled it
- Factors associated with weight regain post-bariatric surgery: a systematic review.Surgical endoscopy · 2021Pooled it
- In Vitro Investigation of the Toxicity Mechanisms of Antidepressant Drugs on Adipose Tissue in 3T3-L1 Cells.Journal of applied toxicology : JAT · 2026Article
- Magnitude and determinants of double burden of malnutrition among married women in Africa: a multi-country analysis from 25 countries.BMC women's health · 2026Article
- Causal Attributions for Obesity and Weight Loss in the Healthy Weight Coaching Program, a 12-Month Online Lifestyle Intervention.Obesity facts · 2026Article
- Review
- Emulation of a Target Trial of Antihypertensive Medications on Weight Change.Journal of general internal medicine · 2026Observational
- Obesity Hacks the Brain's Systems for Weight Loss Resistance.Molecular neurobiology · 2025Review
- Understanding the Increasing Prevalence of Obesity in Patients With Type 1 Diabetes: Strategies for Improving Clinical Care.Obesity (Silver Spring, Md.) · 2025Review
- Can switching to doravirine/lamivudine/tenofovir DF halt or reverse INSTI-associated weight gain?Journal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada · 2025Article
- Corticosteroid Use and Long-Term Changes in Weight and Waist Circumference: The Lifelines Cohort Study.The Journal of clinical endocrinology and metabolism · 2025Article
- Chronicity of obesity and the importance of early treatment to reduce cardiometabolic risk and improve body composition.Obesity pillars · 2025Review
- Childhood Obesity: A Narrative Review.Cureus · 2025Review
- Weight, Anthropometric and Metabolic Changes After Discontinuing Antiretroviral Therapy Containing Tenofovir Alafenamide in People With HIV.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2024Article
- Adipose Tissue Dysfunction and the Role of Adipocyte-Derived Extracellular Vesicles in Obesity and Metabolic Syndrome.Journal of the Endocrine Society · 2024Review
- Overweight, Obesity, and Associated Risk Factors among Students at the Faculty of Medicine, Jazan University.Medicina (Kaunas, Lithuania) · 2024Article
- Observational
- Real World Use of Anti-Obesity Medications and Weight Change in Veterans.Journal of general internal medicine · 2024Article
- Nutrients patterns and attention deficit hyperactivity disorder among Egyptian children: a sibling and community matched case-control study.European journal of clinical nutrition · 2024Article
- Obesity Management in Adults: A Review.JAMA · 2023 · on this mapReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe cause of the obesity epidemic is multifactorial, but may, in part, be related to medication-induced weight gain. While clinicians may strive to do their best to select pharmacotherapy(ies) that has the least negative impact on weight, the literature regarding the weight effects of medication is often limited and devoid of alternative therapies.
resultsAntipsychotics, antidepressants, antihyperglycemics, antihypertensives and corticosteroids all contain medications that were associated with significant weight gain. However, there are several medication alternatives within the majority of these classes associated with weight neutral or even weight loss effects. Further, while not all of the classes of medication examined in this review have weight-favorable alternatives, there exist many other tools to mitigate weight gain associated with medication use, such as changes in dosing, medication delivery or the use of adjunctive therapies.
conclusionMedication-induced weight gain can be frustrating for both the patient and the clinician. As the use of pharmaceuticals continues to increase, it is pertinent for clinicians to consider the weight effects of medications prior to prescribing or in the course of treatment. In the case where it is not feasible to make changes to medication, adjunctive therapies should be considered.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.