ArticleMolecular cell2018
Quantitative Lipid Imaging Reveals a New Signaling Function of Phosphatidylinositol-3,4-Bisphophate: Isoform- and Site-Specific Activation of Akt.
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Article in Molecular cell, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers.
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72citing papers in PubMed
5.3field-weighted citation impact, top 3% of its field
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Who cites it
72 citing papers in PubMed, 138 citations in OpenAlex.
- PI(3,5)PScience advances · 2026Article
- Spatial organization of phosphoinositide signaling.FEBS letters · 2026Review
- The proximal lipid phase of PI3K signaling is confined to the plasma membrane.bioRxiv : the preprint server for biology · 2026Article
- Structural and mechanistic basis of mTORC2 activation of protein kinase AKT/PKB.The Biochemical journal · 2026Review
- Subcellular Cartography of the Phosphoinositide Multiverse.Biochimica et biophysica acta. Molecular and cell biology of lipids · 2026Review
- Cholesterol efflux protein, ABCA1, supports anticancer functions of myeloid immune cells.Science advances · 2026Article
- Non-redundant roles of the phosphoinositide phosphatases PTEN and PIPP in PI3K/AKT signaling in breast cancer.Communications biology · 2025Article
- Androgen deprivation-mediated activation of AKT is enhanced in prostate cancer with TMPRSS2:ERG fusion.The Journal of clinical investigation · 2025Article
- Programmable targeted RNA degradation via dCas13d-directed chaperone-mediated autophagy (dCasCMA).Nature communications · 2025Article
- Physiological roles of phosphoinositides and inositol phosphates: Implications for metabolic dysfunction-associated steatotic liver disease.Clinical science (London, England : 1979) · 2025Review
- Article
- The Inositol-5-Phosphatase SHIP1: Expression, Regulation and Role in Acute Lymphoblastic Leukemia.International journal of molecular sciences · 2025Review
- IFITM2 Modulates Endocytosis Maintaining Neural Stem Cells in Developing Neocortex.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Lysosomal PIPProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Attenuated growth factor signaling during cell death initiation sensitizes membranes towards peroxidation.Nature communications · 2025Article
- Molecular Spies in Action: Genetically Encoded Fluorescent Biosensors Light up Cellular Signals.Chemical reviews · 2024Review
- The actin-binding protein palladin associates with the respiratory syncytial virus matrix protein.Journal of virology · 2024Article
- The LCLAT1/LYCAT acyltransferase is required for EGF-mediated phosphatidylinositol-3,4,5-trisphosphate generation and Akt signaling.Molecular biology of the cell · 2024Article
- Probing and imaging phospholipid dynamics in live cells.Life metabolism · 2024Review
- The interplay between the PI3K/AKT pathway and circadian clock in physiologic and cancer-related pathologic conditions.Cell proliferation · 2024Review
12 more citing papers are in PubMed but not listed here.
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Authors and funding
13 authors at 3 institutions in 2 countries.
Shu-Lin LiuDepartment of Chemistry, University of Illinois at Chicago, Chicago, IL 60607, USA.
Zhi-Gang WangDepartment of Chemistry, University of Illinois at Chicago, Chicago, IL 60607, USA.
Yusi HuDepartment of Chemistry, University of Illinois at Chicago, Chicago, IL 60607, USA.
Yao XinDepartment of Chemistry, University of Illinois at Chicago, Chicago, IL 60607, USA.
Indira SingaramDepartment of Chemistry, University of Illinois at Chicago, Chicago, IL 60607, USA.
Sukhamoy GoraiDepartment of Chemistry, University of Illinois at Chicago, Chicago, IL 60607, USA.
Xin ZhouDepartment of Pharmacology, University of California at San Diego, La Jolla, CA 92093, USA.
Yoonjung ShimDepartment of Chemistry, University of Illinois at Chicago, Chicago, IL 60607, USA.
Jung-Hyun MinDepartment of Chemistry, University of Illinois at Chicago, Chicago, IL 60607, USA.
Liang-Wei GongDepartment of Biological Sciences, University of Illinois at Chicago, Chicago, IL 60607, USA.
Nissim HayDepartment of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, IL 60607, USA.
Jin ZhangDepartment of Pharmacology, University of California at San Diego, La Jolla, CA 92093, USA.
Wonhwa ChoDepartment of Chemistry, University of Illinois at Chicago, Chicago, IL 60607, USA; Department of Genetic Engineering, Kyung Hee University, Yongin 446-701, Republic of Korea. Electronic address: wcho@uic.edu.
University of Illinois Chicago · USUniversity of California San Diego · USKyung Hee University · KR
Funding
Live-cell Activity Architecture in CancerR35CA197622 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Jin Zhang · 2015 to 2026
$11.2MPI3K/PTEN/Akt signaling and the genesis of cancerR01CA090764 · NCI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI Nissim Hay · 2001 to 2026
$9.4MThe Role of Akt in Cell Survival and Cell GrowthR01AG016927 · NIA · UNIVERSITY OF ILLINOIS AT CHICAGO · PI HAY, NISSIM · 1998 to 2023
$9.0MSupplement for Equipment for Lipid Regulation of Cellular Signaling and Protein-Protein InteractionsR35GM122530 · NIGMS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI WONHWA CHO · 2017 to 2026
$6.1MSignal Transduction by PI3K/Akt/mTOR PathwayR01GM111665 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ZHANG, JIN · 2015 to 2018
$1.2MArylamine DNA adduct recognition in eukaryotic nucleotide excision repairR21ES028384 · NIEHS · UNIVERSITY OF RHODE ISLAND · PI CHO, BONGSUP P, MIN, JUNG-HYUN · 2017 to 2018
$443kThe role of a calcium permeable TRP channel in endocytosisR56MH107387 · NIMH · UNIVERSITY OF ILLINOIS AT CHICAGO · PI GONG, LIANG-WEI · 2016 to 2016
$393kNCI NIH HHS R01 CA090764NCI NIH HHS R35 CA197622NIA NIH HHS R01 AG016927NIEHS NIH HHS R21 ES028384NIGMS NIH HHS R01 GM111665NIGMS NIH HHS R35 GM122530NIMH NIH HHS R56 MH107387
Abstract
Activation of class I phosphatidylinositol 3-kinase (PI3K) leads to formation of phosphatidylinositol-3,4,5-trisphophate (PIP
Indexed as
AnimalsCell LineCell MembraneHumansInositol PhosphatesMiceOptical ImagingPhosphatidylinositol 3-KinasesPhosphatidylinositol PhosphatesPhosphatidylinositolsProtein IsoformsProtein TransportProto-Oncogene Proteins c-aktSignal TransductionSingle Molecule ImagingAKT2 protein, humanAKT3 protein, humanInositol Phosphatesphosphatidylinositol 3,4,5-triphosphatephosphatidylinositol 3,4-diphosphatePhosphatidylinositol 3-KinasesPhosphatidylinositol PhosphatesPhosphatidylinositolsProtein IsoformsProto-Oncogene Proteins c-aktAkt activation mechanismPI34P2 quantificationPI3K signalingPIP3 quantification
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