ArticleUltrasound in medicine & biology2018
In Vivo Viscoelastic Response (VisR) Ultrasound for Characterizing Mechanical Anisotropy in Lower-Limb Skeletal Muscles of Boys with and without Duchenne Muscular Dystrophy.
Article in Ultrasound in medicine & biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Characterizing Musculoskeletal Tissue Mechanics Based on Shear Wave Propagation: A Systematic Review of Current Methods and Reported Measurements.Annals of biomedical engineering · 2022Pooled it
- Shear-Wave Anisotropy of the Vastus Lateralis During Low-Level Isometric Contraction Measured with Ultrasound Time-Harmonic Elastography.Annals of biomedical engineering · 2026Article
- VESTA: Machine Learning-Enabled Estimation of ViscoElastic Ratios from On-Axis Spatio-Temporal ARFI Features.bioRxiv : the preprint server for biology · 2026Article
- APRIL: Adaptive Regression-Based Two-Dimensional Quantitative Anisotropy Imaging Using Acoustic Radiation Force Impulse.bioRxiv : the preprint server for biology · 2026Article
- VisR Ultrasound for Monitoring Muscle Fatigue with FES-Induced and Volitional Isometric Contraction of the Rectus Femoris in Participants with Uninjured and Injured Spinal Cords.Annals of biomedical engineering · 2026Article
- Mechanically anisotropic phantoms for magnetic resonance elastography.Magnetic resonance in medicine · 2025Article
- Quantitative Viscoelastic Response (QVisR): Direct Estimation of Viscoelasticity With Neural Networks.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2024Article
- Feasibility of Phase Velocity Imaging Using Multi Frequency Oscillation-Shear Wave Elastography.IEEE transactions on bio-medical engineering · 2024Article
- Draft Guidance for Industry Duchenne Muscular Dystrophy, Becker Muscular Dystrophy, and Related Dystrophinopathies - Developing Potential Treatments for the Entire Spectrum of Disease.Journal of neuromuscular diseases · 2024Article
- VisR Ultrasound With Non-Normal ARF-AoS Incidence Interrogates Both Shear and Young's Elastic Moduli in Transversely Isotropic Materials.IEEE open journal of ultrasonics, ferroelectrics, and frequency control · 2024Article
- Parametric Analysis of SV Mode Shear Waves in Transversely Isotropic Materials Using Ultrasonic Rotational 3-D SWEI.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2022Article
- Shear-Wave Elastography and Viscosity PLUS for the Assessment of Peripheric Muscles in Healthy Subjects: A Pre- and Post-Contraction Study.Diagnostics (Basel, Switzerland) · 2022Article
- Quantitative Estimation of Mechanical Anisotropy Using Acoustic Radiation Force (ARF)-Induced Peak Displacements (PD): In Silico and Experimental Demonstration.IEEE transactions on medical imaging · 2022Article
- Full Characterization of in vivo Muscle as an Elastic, Incompressible, Transversely Isotropic Material Using Ultrasonic Rotational 3D Shear Wave Elasticity Imaging.IEEE transactions on medical imaging · 2022Article
- Electronic Point Spread Function Rotation Using a Three-Row Transducer for ARFI-Based Elastic Anisotropy Assessment: In Silico and Experimental Demonstration.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2021Article
- Viscoelastic Response Ultrasound Derived Relative Elasticity and Relative Viscosity Reflect True Elasticity and Viscosity: In Silico and Experimental Demonstration.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2020Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Our group has previously found that in silico, mechanical anisotropy may be interrogated by exciting transversely isotropic materials with geometrically asymmetric acoustic radiation force excitations and then monitoring the associated induced displacements in the region of excitation. We now translate acoustic radiation force-based anisotropy assessment to human muscle in vivo and investigate its clinical relevance to monitoring muscle degeneration in Duchenne muscular dystrophy (DMD). Clinical anisotropy assessments were performed using Viscoelastic Response ultrasound, with a degree of anisotropy reflected by the ratios of Viscoelastic Response relative elasticity (RE) or relative viscosity (RV) measured with the asymmetric radiation force oriented parallel versus perpendicular to muscle fiber alignment. In vivo results from rectus femoris and gastrocnemius muscles of boys aged ∼7.9-10.4 y indicate that RE and RV anisotropy ratios in rectus femoris muscles of boys with DMD were significantly higher than those of healthy control boys (RE: DMD = 1.51 ± 0.87, control = 0.99 ± 0.69, p = 0.04, Wilcoxon rank sum test; RV: DMD = 1.04 ± 0.71, control = 0.74 ± 0.22, p = 0.02). In the gastrocnemius muscle, only the RV anisotropy ratio was significantly higher in dystrophic than control patients (DMD = 1.23 ± 0.35, control = 0.88 ± 0.31, p = 0.04). In the dystrophic rectus femoris muscle, the RE anisotropy ratio was inversely correlated (slope = -0.03/lbf, r = -0.43, p = 0.07, Pearson correlation) with quantitative muscle testing functional output measures but was not correlated with quantitative muscle testing in the dystrophic gastrocnemius. These results suggest that Viscoelastic Response RE and RV measures reflect differences in mechanical anisotropy associated with functional impairment with dystrophic degeneration that are relevant to monitoring DMD clinically.
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