Evidence map›Paper›PMID 30173667›Full record

ArticleBMC medicine2018

Bayesian adaptive algorithms for locating HIV mobile testing services.

Gregg S Gonsalves, J Tyler Copple, Tyler Johnson, A David Paltiel, Joshua L Warren

Abstract read
In one paragraph

Article in BMC medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Integrating testing volume into bandit algorithms for infectious disease surveillance.Journal of the Royal Statistical Society. Series A, (Statistics in Society) · 2025
    Article
  2. Article
  3. Article
  4. Maximizing the Efficiency of Active Case Finding for SARS-CoV-2 Using Bandit Algorithms.Medical decision making : an international journal of the Society for Medical Decision Making · 2021
    Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Gregg S GonsalvesDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, 60 College Street, New Haven, CT, USA. gregg.gonsalves@yale.edu.ORCID http://orcid.org/0000-0002-5789-9841
J Tyler CoppleDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, 60 College Street, New Haven, CT, USA.
Tyler JohnsonDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, 60 College Street, New Haven, CT, USA.
A David PaltielDepartment of Health Policy and Management, Yale School of Public Health, 60 College Street, New Haven, CT, USA.
Joshua L WarrenDepartment of Biostatistics, Yale School of Public Health, 60 College Street, New Haven, CT, USA.

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Development and application of a new simulation model for COVID-19R01AI042006 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI Kenneth Alan Freedberg, Anne Neilan · 1998 to 2026
$12.9M
Institutional Career Development CoreKL2TR001862 · NCATS · YALE UNIVERSITY · PI CANTLEY, LLOYD G, EDELMAN, E. JENNIFER · 2016 to 2025
$12.2M
Making Better Decisions: Policy Modeling for AIDS and Drug AbuseR01DA015612 · NIDA · STANFORD UNIVERSITY · PI OWENS, DOUGLAS K · 2002 to 2017
$9.4M
Novel approaches to the design and evaluation of combination HIV preventionR01MH105203 · NIMH · YALE UNIVERSITY · PI PALTIEL, A. DAVID · 2014 to 2018
$3.3M
Agence Nationale de la Recherche ANR 11 IDEX000502Agence Nationale de la Recherche ANR11LABX0091NCATS NIH HHS KL2 TR001862NCATS NIH HHS UL1 TR001863NIDA NIH HHS R01 DA015612NIMH NIH HHS R01 MH105203NIMH NIH HHS R01MH105203
6 · The paper itself

Abstract

backgroundWe have previously conducted computer-based tournaments to compare the yield of alternative approaches to deploying mobile HIV testing services in settings where the prevalence of undetected infection may be characterized by 'hotspots'. We report here on three refinements to our prior assessments and their implications for decision-making. Specifically, (1) enlarging the number of geographic zones; (2) including spatial correlation in the prevalence of undetected infection; and (3) evaluating a prospective search algorithm that accounts for such correlation.

methodsBuilding on our prior work, we used a simulation model to create a hypothetical city consisting of up to 100 contiguous geographic zones. Each zone was randomly assigned a prevalence of undetected HIV infection. We employed a user-defined weighting scheme to correlate infection levels between adjacent zones. Over 180 days, search algorithms selected a zone in which to conduct a fixed number of HIV tests. Algorithms were permitted to observe the results of their own prior testing activities and to use that information in choosing where to test in subsequent rounds. The algorithms were (1) Thompson sampling (TS), an adaptive Bayesian search strategy; (2) Besag York Mollié (BYM), a Bayesian hierarchical model; and (3) Clairvoyance, a benchmarking strategy with access to perfect information.

resultsOver 250 tournament runs, BYM detected 65.3% (compared to 55.1% for TS) of the cases identified by Clairvoyance. BYM outperformed TS in all sensitivity analyses, except when there was a small number of zones (i.e., 16 zones in a 4 × 4 grid), wherein there was no significant difference in the yield of the two strategies. Though settings of no, low, medium, and high spatial correlation in the data were examined, differences in these levels did not have a significant effect on the relative performance of BYM versus TS.

conclusionsBYM narrowly outperformed TS in our simulation, suggesting that small improvements in yield can be achieved by accounting for spatial correlation. However, the comparative simplicity with which TS can be implemented makes a field evaluation critical to understanding the practical value of either of these algorithms as an alternative to existing approaches for deploying HIV testing resources.

Indexed as

Bayes TheoremAlgorithmsHIV InfectionsHumansProspective StudiesSerologic TestsTelemedicine

Identifiers

PMID30173667
PMCPMC6120098

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.