SynthesisEating and weight disorders : EWD2019
Anorexia nervosa and heart disease: a systematic review.
Synthesis in Eating and weight disorders : EWD, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
48 citing papers in PubMed, 3 syntheses or guidelines pooled it, 97 citations in OpenAlex.
- Heart Rate Variability in Anorexia Nervosa: A Systematic Review and Meta-Analysis on the Moderating Role of Measurement Duration and Clinical Stage.European eating disorders review : the journal of the Eating Disorders Association · 2026Pooled it
- Systematic Review and Meta-Analysis of Mortality in Patients With Anorexia Nervosa.The International journal of eating disorders · 2026Pooled it
- Autonomic Nervous System Function in Anorexia Nervosa: A Systematic Review.Frontiers in neuroscience · 2021Pooled it
- De novo electrocardiographic abnormalities in persons living with HIV.Scientific reports · 2021Trial
- Exploring MDMA assisted therapy in eating disorders: mechanisms, clinical evidence, and future directions.Journal of eating disorders · 2025Review
- Decoding the Spectrum of Anorexia Nervosa: Clinical Impact, Molecular Insights, and Therapeutic Perspectives.Biomolecules · 2025Review
- The Role of Age at Onset on the Clinical Course and Biochemical Parameters of Anorexia Nervosa.Journal of personalized medicine · 2025Article
- Article
- Excessive vitamin BJournal of eating disorders · 2025Article
- Incidence and Risk of Cardiovascular Outcomes in Patients With Anorexia Nervosa.JAMA network open · 2024Article
- Harm reduction in severe and long-standing Anorexia Nervosa: part of the journey but not the destination-a narrative review with lived experience.Journal of eating disorders · 2024Review
- Perinatal depression and risk of maternal cardiovascular disease: a Swedish nationwide study.European heart journal · 2024Article
- Outcomes in people with eating disorders: a transdiagnostic and disorder-specific systematic review, meta-analysis and multivariable meta-regression analysis.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2024Article
- Shared genetic risk between anorexia nervosa and cardiovascular disease events: Evidence from genome-wide association studies.Brain and behavior · 2024Article
- Dietary Effects of Fasting on the Lipid Panel.Current cardiology reviews · 2024Review
- A Mendelian randomization study of the effect of mental disorders on cardiovascular disease.Frontiers in cardiovascular medicine · 2024Article
- Maximal Resistance Training in the Treatment of Anorexia Nervosa - A Case Report Series.International journal of exercise science · 2024Article
- The Impact of Clinical Factors, Vitamin B12 and Total Cholesterol on Severity of Anorexia Nervosa: A Multicentric Cross-Sectional Study.Nutrients · 2023Article
- Common practical questions - and answers - at the British Association for Psychopharmacology child and adolescent psychopharmacology course.Journal of psychopharmacology (Oxford, England) · 2023Review
- Impact of BMIFrontiers in pediatrics · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Anorexia nervosa (AN) is an eating disorder that most frequently afflicts females in adolescence. In these subjects, cardiovascular complications are the main cause of morbidity and mortality. Aim of this review is to analyze the hemodynamic, pro-arrhythmic and structural changes occurring during all phases of this illness, including re-feeding. A systematic literature search was performed on studies in the MEDLINE database, from its inception until September 2017, with PUBMED interface focusing on AN and cardiovascular disease. This review demonstrated that the most common cardiac abnormalities in AN are bradycardia and QT interval prolongation, which may occasionally degenerate into ventricular arrhythmias such as Torsades des Pointes or ventricular fibrillation. As these arrhythmias may be the substrate of sudden cardiac death (SCD), they require cardiac monitoring in hospital. In addition, reduced cardiac mass, with smaller volumes and decreased cardiac output, may be found. Furthermore, mitral prolapse and a mild pericardial effusion may occur, the latter due to protein deficiency and low levels of thyroid hormone. In anorectic patients, some cases of hypercholesterolemia may be present; however, conclusive evidence that AN is an atherogenic condition is still lacking, although a few cases of myocardial infarction have been reported. Finally, refeeding syndrome (RFS), which occurs during the first days of refeeding, may engender a critically increased risk of acute, life-threatening cardiac complications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.