Evidence map›Paper›PMID 30173355›Full record

ArticleGlycoconjugate journal2018

Chemical synthesis of 4-azido-β-galactosamine derivatives for inhibitors of N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase.

Seanghai Hor, Takumi Kodama, Nobuo Sugiura, Hikaru Kondou, Mio Yanagida, Keiya Yanagisawa, Aoki Shibasawa, Bunta Tsuzuki, Naoto Fukatsu, Kazuya Nagao and 5 more

Abstract read
PubMed Publisher
In one paragraph

Article in Glycoconjugate journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 1 country.

Seanghai HorDepartment of Chemistry, Aichi University of Education, Igaya, Kariya, Aichi, 448-8542, Japan.
Takumi KodamaDepartment of Chemistry, Aichi University of Education, Igaya, Kariya, Aichi, 448-8542, Japan.
Nobuo SugiuraInstitute for Molecular Science of Medicine, Aichi Medical University, 1-1 Yazakokarimata, Nagakute, Aichi, 480-1195, Japan.
Hikaru KondouDepartment of Chemistry, Aichi University of Education, Igaya, Kariya, Aichi, 448-8542, Japan.
Mio YanagidaDepartment of Chemistry, Aichi University of Education, Igaya, Kariya, Aichi, 448-8542, Japan.
Keiya YanagisawaDepartment of Chemistry, Aichi University of Education, Igaya, Kariya, Aichi, 448-8542, Japan.
Aoki ShibasawaDepartment of Chemistry, Aichi University of Education, Igaya, Kariya, Aichi, 448-8542, Japan.
Bunta TsuzukiDepartment of Chemistry, Aichi University of Education, Igaya, Kariya, Aichi, 448-8542, Japan.
Naoto FukatsuDepartment of Chemistry, Aichi University of Education, Igaya, Kariya, Aichi, 448-8542, Japan.
Kazuya NagaoDepartment of Chemistry, Aichi University of Education, Igaya, Kariya, Aichi, 448-8542, Japan.
Kenji YamanaAichi Gakuin University, 12 Araike, Iwasaki-cho, Nisshin, Aichi, 470-0195, Japan.
Kazuya I P J HidariJunior College Division, University of Aizu, Ikki-machi, Aizuwakamatsu, Fukushima, 965-8570, Japan.
Hideto WatanabeInstitute for Molecular Science of Medicine, Aichi Medical University, 1-1 Yazakokarimata, Nagakute, Aichi, 480-1195, Japan.
Osami HabuchiDepartment of Chemistry, Aichi University of Education, Igaya, Kariya, Aichi, 448-8542, Japan.
Hirofumi NakanoDepartment of Chemistry, Aichi University of Education, Igaya, Kariya, Aichi, 448-8542, Japan. hnakano@auecc.aichi-edu.ac.jp.ORCID http://orcid.org/0000-0002-7632-8630
Aichi University of Education · JPAichi Medical University · JPAichi Gakuin University · JPUniversity of Aizu · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chondroitin sulfate E (CS-E) plays a crucial role in diverse processes ranging from viral infection to neuroregeneration. Its regiospecific sulfation pattern, generated by N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase (GalNAc4S-6ST), is the main structural determinant of its biological activity. Inhibitors of GalNAc4S-6ST can serve as powerful tools for understanding physiological functions of CS-E and its potential therapeutic leads for human diseases. A family of new 4-acylamino-β-GalNAc derivatives and 4-azido-β-GalNAc derivatives were synthesized for their potential application as inhibitors of GalNAc4S-6ST. The target compounds were evaluated for their inhibitory activities against GalNAc4S-6ST. The results revealed that 4-pivaloylamino- and 4-azido-β-GalNAc derivatives displayed evident activities against GalNAc4S-6ST with IC

Indexed as

AmidesAnimalsEnzyme InhibitorsGalactosamineHumansSulfotransferasesAmidesEnzyme InhibitorsGalactosamineN-acetylgalactosamine 4-sulfate 6-O-sulfotransferaseSulfotransferasesChemical synthesisInhibitorN-Acetylgalactosamine 4-sulfate 6-O-sulfotransferaseSulfotransferase

Identifiers

PMID30173355
OpenAlexW2889240771

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.