ArticleEndocrine2019
The relationship between quality of life, cognition, and thyroid status in Graves' disease.
Article in Endocrine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 45 citations in OpenAlex.
- Selenium in the treatment of mild-to-moderate Graves' orbitopathy: a 5-year prospective controlled cohort study.Endocrine · 2024Trial
- Brain fatigue in Graves' disease: symptoms and presentation of a possible mechanism at the cellular level.European thyroid journal · 2026Review
- Novel ThyPRO-39-based nomogram for identifying impaired quality of life in Graves' hyperthyroidism outpatients: development and internal validation.Endocrine connections · 2026Article
- Quality of life in refractory Graves' hyperthyroidism: a cross-sectional study comparing long-term ATDs therapy versus L-T4 replacement after iodine-131.Frontiers in endocrinology · 2026Observational
- PERSPECTIVE: Prioritizing quality of life in the management of hyperthyroidism: an expert clinical perspective.Endocrine connections · 2026Review
- Development and external validation of a nomogram for identifying patients with thyroid eye disease who screen positive for depressive symptoms: a two-center study.Frontiers in endocrinology · 2026Observational
- Patients undergoing thyroid surgery suffer preoperatively from poor quality of life.Journal of endocrinological investigation · 2025Article
- Thyroid Function and Cognitive Decline: A Narrative Review.Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists · 2024Review
- Psychiatric complications in Graves' disease.European thyroid journal · 2024Article
- Altered dynamic brain activity and functional connectivity in thyroid-associated ophthalmopathy.Human brain mapping · 2023Article
- The relationship between mental fatigue, depression, and cognition in Graves' disease.European thyroid journal · 2023Article
- Increased brain iron in patients with thyroid-associated ophthalmopathy: a whole-brain analysis.Frontiers in endocrinology · 2023Article
- Computed tomography and magnetic resonance imaging approaches to Graves' ophthalmopathy: a narrative review.Frontiers in endocrinology · 2023Review
- 3.0 T multi-parametric MRI reveals metabolic and microstructural abnormalities in the posterior visual pathways in patients with thyroid eye disease.Frontiers in neuroscience · 2023Article
- Reduced cortical complexity in patients with thyroid-associated ophthalmopathy.Brain imaging and behavior · 2022Article
- Patient-Reported Outcomes Following Total Thyroidectomy for Graves' Disease.Thyroid : official journal of the American Thyroid Association · 2022Article
- Altered Long- and Short-Range Functional Connectivity Density in Patients With Thyroid-Associated Ophthalmopathy: A Resting-State fMRI Study.Frontiers in neurology · 2022Article
- The relationship between atherosclerotic disease and relapse during ATD treatment.Frontiers in cardiovascular medicine · 2022Article
- The longer the antithyroid drug is used, the lower the relapse rate in Graves' disease: a retrospective multicenter cohort study in Korea.Endocrine · 2021Article
- Eye symptoms in patients with benign thyroid diseases.Scientific reports · 2021Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo assess quality of life (QoL) and cognitive function among Graves' disease (GD) patients with different thyroid status, with and without ophthalmopathy.
methodsThis is a cross-sectional clinic-based study involving 154 patients with GD (81.27% were female, mean age 45.6 ± SD 11.2 years) and 54 (35.06%) had ophthalmopathy. Data were collected after an informed consent from all patients was obtained. All patients completed the 36-Item Short Form Health Survey and Mini-Mental State Examination. Patients with ophthalmopathy also completed the Graves' Orbitopathy Quality of Life Questionnaire.
resultsPatients with hyperthyroidism presented a greater impairment in QoL when compared to euthyroidism group. A lower score in physical role functioning was found in both subgroups with active disease (hyperthyroidism and euthyroidism using thionamides). A lower score was also seen in visual function, only in patients with hyperthyroidism, without difference in appearance. No difference was found in cognition between patients. Younger ages at diagnosis, male sex, euthyroidism and absence of ophthalmopathy were factors associated with better QoL, as well as a shorter disease duration was associated with better recall, attention and calculation.
conclusionsAn impairment in QoL among patients with active GD was evidenced, even in those receiving thionamides and in euthyroidism. Ophthalmopathy was a factor associated with a poor QoL and no clear evidence of cognitive impairment was demonstrated.
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