Evidence map›Paper›PMID 30173319›Full record

ArticleEuropean archives of psychiatry and clinical neuroscience2019

Reduced volumes of the external and internal globus pallidus in male heroin addicts: a postmortem study.

Ulf J Müller, Christian Mawrin, Thomas Frodl, Henrik Dobrowolny, Stefan Busse, Hans-Gert Bernstein, Bernhard Bogerts, Kurt Truebner, Johann Steiner

Abstract read
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In one paragraph

Article in European archives of psychiatry and clinical neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Impairment of the GABAergic system in the anterior insular cortex of heroin-addicted males.European archives of psychiatry and clinical neuroscience · 2025
    Article
  7. Article
  8. Reduced anterior insular cortex volume in male heroin addicts: a postmortem study.European archives of psychiatry and clinical neuroscience · 2023
    Article
  9. Review
  10. Reduced habenular volumes and neuron numbers in male heroin addicts: a post-mortem study.European archives of psychiatry and clinical neuroscience · 2021
    Article
  11. Article
  12. Article
  13. Opioid and neuroHIV Comorbidity - Current and Future Perspectives.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2020
    Review
  14. The ventral pallidum and relapse in alcohol seeking.British journal of pharmacology · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Ulf J MüllerDepartment of Psychiatry and Psychotherapy, University of Magdeburg, 39120, Magdeburg, Germany. ulfmueller@gmail.com.
Christian MawrinCenter for Behavioral Brain Sciences, Magdeburg, Germany.
Thomas FrodlDepartment of Psychiatry and Psychotherapy, University of Magdeburg, 39120, Magdeburg, Germany.
Henrik DobrowolnyDepartment of Psychiatry and Psychotherapy, University of Magdeburg, 39120, Magdeburg, Germany.
Stefan BusseDepartment of Psychiatry and Psychotherapy, University of Magdeburg, 39120, Magdeburg, Germany.
Hans-Gert BernsteinDepartment of Psychiatry and Psychotherapy, University of Magdeburg, 39120, Magdeburg, Germany.
Bernhard BogertsDepartment of Psychiatry and Psychotherapy, University of Magdeburg, 39120, Magdeburg, Germany.
Kurt TruebnerInstitute of Legal Medicine, University of Duisburg-Essen, Essen, Germany.
Johann SteinerDepartment of Psychiatry and Psychotherapy, University of Magdeburg, 39120, Magdeburg, Germany. johann.steiner@med.ovgu.de.
Center for Behavioral Brain Sciences · DEUniversity Hospital Magdeburg · DEUniversity of Duisburg-Essen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Deep brain stimulation (DBS) of the globus pallidus internus was recently proposed as a potential new treatment target for opioid addiction. DBS requires computer-assisted-3D planning to implant the stimulation electrode precisely. As volumes of brain regions may differ in addiction compared to healthy controls, our aim was to investigate possible volume differences in addicts compared to healthy controls. Volumes of the globus pallidus externus (PE) and internus (PI) in heroin addicts (n = 14) and healthy controls (n = 12) were assessed using morphometry of serial whole-brain sections. Total brain volume was larger in the heroin group (mean 1479 ± 62 cm

Indexed as

AdultAutopsyGlobus PallidusHeroin DependenceHumansMaleMiddle AgedYoung AdultAddictionDBSDeep brain stimulationGlobus pallidus externusGlobus pallidus internusHeroinMorphometryPostmortemVolumetry

Identifiers

PMID30173319
OpenAlexW2888850818

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.