Evidence map›Paper›PMID 30173282›Full record

ArticleEsophagus : official journal of the Japan Esophageal Society2019

Construction of a risk model for the development of metachronous squamous cell carcinoma after endoscopic resection of esopahageal squamous cell carcinoma.

Yuji Urabe, Kenichi Kagemoto, Koki Nakamura, Takeshi Mizumoto, Yoji Sanomura, Shiro Oka, Hidenori Ochi, Shinji Tanaka, Kazuaki Chayama

Abstract read
PubMed Publisher
In one paragraph

Article in Esophagus : official journal of the Japan Esophageal Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Alcohol Consumption,Life (Basel, Switzerland) · 2022
    Review
  5. Article
  6. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Yuji UrabeDivision of Regeneration and Medicine Center for Translational and Clinical Research, Hiroshima University Hospital, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan. beyan13@hiroshima-u.ac.jp.ORCID http://orcid.org/0000-0003-0942-1541
Kenichi KagemotoDepartment of Gastroenterology and Metabolism, Hiroshima University Hospital, Hiroshima, Japan.
Koki NakamuraDepartment of Gastroenterology and Metabolism, Hiroshima University Hospital, Hiroshima, Japan.
Takeshi MizumotoDepartment of Gastroenterology and Metabolism, Hiroshima University Hospital, Hiroshima, Japan.
Yoji SanomuraDepartment of Endoscopy, Hiroshima University Hospital, Hiroshima, Japan.
Shiro OkaDepartment of Gastroenterology and Metabolism, Hiroshima University Hospital, Hiroshima, Japan.
Hidenori OchiDepartment of Endoscopy, Hiroshima University Hospital, Hiroshima, Japan.
Shinji TanakaDepartment of Gastroenterology and Metabolism, Hiroshima University Hospital, Hiroshima, Japan.
Kazuaki ChayamaDepartment of Endoscopy, Hiroshima University Hospital, Hiroshima, Japan.
Hiroshima University Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPreviously, we identified that rs1229984 in ADH1B, rs671 in ALDH2, and smoking status were independently associated with the risk of developing metachronous squamous cell carcinoma (SCC) after endoscopic resection (ER) for esophageal SCC (ESCC). However, this analysis included cases with short-term follow-up. In the present study, we investigated the environmental and genetic factors associated with developing metachronous SCC using long-term follow-up observation after ER for ESCC.

methodsOne hundred and thirty ESCC patients who underwent treatment with ER were followed up using endoscopy for ≥ 30 months. We investigated the incidence of, and genetic/environmental factors associated with, metachronous SCC development after ER for ESCC. We also analyzed the potential risk factors for multiple metachronous SCC development using Cox's proportional hazards model. Moreover, we constructed a risk model for the development of metachronous SCC after ER for ESCC.

resultsMale, rs1229984, rs671, alcohol consumption (> 20 g/day), smoking, and multiple Lugol-voiding lesions (LVLs) significantly affected the incidence of multiple metachronous SCCs. Multiple Cox proportional analysis revealed that rs1229984, rs671, alcohol consumption, smoking, and multiple LVLs were independently associated with the risk of developing metachronous SCC. Patients who had ≤ 2 risk factors did not develop metachronous SCC, and the risk of developing metachronous SCC in patients with ≥ 3 risk factors was significantly higher than in patients with ≤ 2 risk factors.

conclusionThe risk model using these 5 genetic and environmental factors is useful as an indication for multiple metachronous development in ESCC patients.

Indexed as

EsophagoscopyAdultAgedAlcohol DehydrogenaseAlcohol DrinkingAldehyde Dehydrogenase, MitochondrialEsophageal NeoplasmsEsophageal Squamous Cell CarcinomaFemaleFollow-Up StudiesHumansMaleMiddle AgedNeoplasms, Second PrimaryPolymorphism, Single NucleotidePostoperative ComplicationsADH1B protein, humanAlcohol DehydrogenaseAldehyde Dehydrogenase, MitochondrialALDH2 protein, humanEsophageal squamous cell carcinomaMetachronous multiple SCCRisk model

Identifiers

PMID30173282
OpenAlexW2889467588

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.