Evidence map›Paper›PMID 30173058›Full record

ArticleJournal of affective disorders2019

Neural connectivity during affect labeling predicts treatment response to psychological therapies for social anxiety disorder.

Katherine S Young, Richard T LeBeau, Andrea N Niles, Kean J Hsu, Lisa J Burklund, Bita Mesri, Darby Saxbe, Matthew D Lieberman, Michelle G Craske

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of affective disorders, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 29 citations in OpenAlex.

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  8. Neurocircuitry of treatment in anxiety disorders.Biomarkers in neuropsychiatry · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Katherine S YoungDepartment of Psychology, University of California, Los Angeles, 405 Hilgard Avenue, Los Angeles, USA.
Richard T LeBeauDepartment of Psychology, University of California, Los Angeles, 405 Hilgard Avenue, Los Angeles, USA.
Andrea N NilesDepartment of Psychiatry, University of California, San Francisco, USA.
Kean J HsuUniversity of Texas at Austin, USA.
Lisa J BurklundDepartment of Psychology, University of California, Los Angeles, 405 Hilgard Avenue, Los Angeles, USA.
Bita MesriDepartment of Psychology, University of California, Los Angeles, 405 Hilgard Avenue, Los Angeles, USA.
Darby SaxbeDepartment of Psychology, University of Southern California, USA.
Matthew D LiebermanDepartment of Psychology, University of California, Los Angeles, 405 Hilgard Avenue, Los Angeles, USA.
Michelle G CraskeDepartment of Psychology, University of California, Los Angeles, 405 Hilgard Avenue, Los Angeles, USA. Electronic address: craske@psych.ucla.edu.
University of California, Los Angeles · USThe University of Texas at Austin · USUniversity of California, San Francisco · USUniversity of Southern California · US

Funding

Neural mediators of behavior therapy for anxietyR21MH081299 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CRASKE, MICHELLE G · 2008 to 2009
$402k
NIMH NIH HHS R21 MH081299
6 · The paper itself

Abstract

backgroundAlthough psychological treatments for social anxiety disorder (SAD) can be highly effective, many individuals do not respond to treatment. Identifying factors associated with improved outcomes can facilitate individualized treatment choices. We investigated whether patterns of neural connectivity predicted treatment responses and whether treatment type, cognitive behavioral therapy (CBT) or acceptance and commitment therapy (ACT), moderated this effect.

methodsParticipants with SAD (n = 34) underwent fMRI prior to treatment and completed implicit and explicit emotion regulation tasks. Neural connectivity measures were estimates of amygdala-prefrontal cortex connectivity. Treatment responder status was defined using the 'clinically significant change index' (Loerinc et al., 2015).

resultsRight amygdala-right ventrolateral prefrontal cortex connectivity during implicit emotion regulation was a significant predictor of treatment response (OR = 9.01, 95% CI = 1.77, 46.0, p = .008). Stronger inverse connectivity was associated with greater likelihood of treatment response. There were no significant neural moderators of treatment response to CBT versus ACT. LIMITATIONS: The primary limitation of this work was the small sample size which restricted the power to detect significant moderation effects, and results should be interpreted as preliminary.

conclusionsAmygdala-vlPFC connectivity during affect labeling predicted treatment responder status following CBT or ACT for social anxiety disorder. This suggests that the functioning of neural circuitry supporting emotion regulation capacities may be a 'gateway' to receiving benefit from psychological treatments. Future work should aim to replicate this effect in a larger sample and consider methods for enhancing functional connectivity within this circuitry as a potential treatment adjunct.

Indexed as

Cognitive Behavioral TherapyAdultAmygdalaEmotionsFemaleHumansMagnetic Resonance ImagingMaleNeural PathwaysPhobia, SocialPrefrontal CortexYoung AdultAmygdalaEmotion regulationfMRIPrefrontal cortexSocial anxiety disorder

Identifiers

PMID30173058
PMCPMC6816743
OpenAlexW2885160633

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.