ArticlePsychiatry research2018
Sex differences in hedonic judgement of odors in schizophrenia cases and healthy controls.
Article in Psychiatry research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- Olfactory Dysfunction in Mental Illness.Current allergy and asthma reports · 2023Review
- A study on the relationship between odor hedonic ratings and individual odor detection threshold.Scientific reports · 2022Article
- Pleasant and unpleasant odor identification ability is associated with distinct dimensions of negative symptoms transdiagnostically in psychotic disorders.Schizophrenia research · 2022Article
- Odor hedonics coding in the vertebrate olfactory bulb.Cell and tissue research · 2021Review
- Sex Differences in Odor Hedonic Perception: An Overview.Frontiers in neuroscience · 2021Review
- Assessment of odor hedonic perception: the Sniffin' sticks parosmia test (SSParoT).Scientific reports · 2020Article
- Normal sexual dimorphism in theory of mind circuitry is reversed in Schizophrenia.Social neuroscience · 2019Article
- The role of hedonics in the Human Affectome.Neuroscience and biobehavioral reviews · 2019Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
The neurocircuitries subserving affective and olfactory processes overlap, are sexually dimorphic, and show disruptions in schizophrenia, suggesting their intersection may be a window on the core process producing psychosis. This study investigated diagnostic and sex differences in hedonic judgments of odors and smell identification in 26 schizophrenia cases and 27 healthy controls. Associations between olfaction measures and psychiatric symptoms were also examined. Cases and controls had similar identification accuracy of unpleasant odors, but cases were significantly less accurate in naming pleasant odors. In cases, greater negative symptom severity was related to abnormal hedonic judgments; specifically, higher pleasantness ratings for unpleasant odors and higher unpleasantness ratings for pleasant odors. Greater positive symptom severity was associated with lower pleasantness ratings for neutral odors. Regarding sex differences, male cases and female controls rated pleasant odors as significantly more unpleasant than male controls. Correlations between depression severity and pleasantness ratings of neutral odors were in opposite directions in male and female cases. These results suggest that a normal sexual dimorphism in the circuitry for hedonic odor judgments may interact with schizophrenia pathology, supporting the utility of olfactory hedonics as a sex-specific biomarker of this pathology.
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Registered trials
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