ArticlePsychoneuroendocrinology2019
Limbic response to stress linking life trauma and hypothalamus-pituitary-adrenal axis function.
Article in Psychoneuroendocrinology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 61 citations in OpenAlex.
- Association between influenza A virus and SARS-CoV-2 infections and mood disorders.Brain, behavior, & immunity - health · 2026Article
- MASSAG model: Towards an integrative neuroscience framework linking emotional trauma, pain, and mechanisms of force-based manipulations.Neuroscience and biobehavioral reviews · 2026Review
- Impact of parental adverse childhood experiences on offspring anxiety and depressive symptoms: a three-year longitudinal study.BMC psychology · 2026Article
- Early-life adversity alters adult nucleus incertus neurons: implications for neuronal mechanisms of increased stress and compulsive behavior vulnerability.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Characterization of sleep difficulties in maltreated children and adolescents.European journal of pediatrics · 2024Article
- Review of the direct and indirect effects of hyperglycemia on the HPA axis in T2DM and the co-occurrence of depression.BMJ open diabetes research & care · 2024Review
- The Role of Perceived Stress in the Relation between Childhood Maltreatment and Severity of Alcohol Use Disorder: A Mediation Analysis.European addiction research · 2024Article
- Hypothalamus volume mediates the association between adverse childhood experience and PTSD development after adulthood trauma.Translational psychiatry · 2023Article
- Sex differences in neural responses to stress and drug cues predicts future drug use in individuals with substance use disorder.Drug and alcohol dependence · 2023Article
- Chronic pain, chronic stress and substance use: overlapping mechanisms and implications.Frontiers in pain research (Lausanne, Switzerland) · 2023Review
- The effects of androgen deprivation on working memory and quality of life in prostate cancer patients: The roles of hypothalamic connectivity.Cancer medicine · 2022Observational
- Early life stress and substance use disorders: The critical role of adolescent substance use.Pharmacology, biochemistry, and behavior · 2022Review
- Distinct stress-related medial prefrontal cortex activation in women with depression with and without childhood maltreatment.Depression and anxiety · 2022Article
- Alcohol's Negative Emotional Side: The Role of Stress Neurobiology in Alcohol Use Disorder.Alcohol research : current reviews · 2022Review
- Promoting brain health through physical activity among adults exposed to early life adversity: Potential mechanisms and theoretical framework.Neuroscience and biobehavioral reviews · 2021Review
- Childhood trauma and cardiometabolic risk in severe mental disorders: The mediating role of cognitive control.European psychiatry : the journal of the Association of European Psychiatrists · 2021Article
- The social ecology of childhood and early life adversity.Pediatric research · 2021Review
- Childhood Trauma and Mental Health Status in General Population: A Series Mediation Examination of Psychological Distress in COVID-19 Pandemic and Global Sleep Quality.Frontiers in psychiatry · 2021Article
- G Protein-Coupled Estrogen Receptor Immunoreactivity Fluctuates During the Estrous Cycle and Show Sex Differences in the Amygdala and Dorsal Hippocampus.Frontiers in endocrinology · 2020Article
- Neurobiological mechanisms underlying sex-related differences in stress-related disorders: Effects of neuroactive steroids on the hippocampus.Frontiers in neuroendocrinology · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Trauma alters neuroendocrine responses to stress and increases vulnerability to stress-related disorders. Yet, relationships among trauma, stress-induced neural changes and hypothalamic-pituitary-adrenal (HPA) axis activity have not been determined. The present study used functional magnetic resonance imaging to investigate the impact of life trauma on basal cortisol levels and neural responses to acute stress in 73 healthy individuals during brief stress and neutral-relaxing imagery using a well-established, individualized imagery method. We hypothesized that trauma experience would have a negative impact on brain function, resulting in altered basal cortisol levels via dysregulated neural control over the HPA axis system. Results showed that higher life trauma exposure was significantly associated with lower basal cortisol levels. Neuroimaging results indicated that both higher life trauma and low morning cortisol levels were associated with increased response to acute stress in limbic-medial temporal lobe (MTL) regions including the amygdala and hippocampus. A mediation analysis showed that increased limbic-MTL response to stress mediated the relationship between life trauma and low cortisol levels. Findings revealed a significant impact of lifetime trauma on neural responses to acute stress and HPA axis activity. Life trauma may sensitize limbic-MTL regions and its related peripheral systems, which could compromise stress regulation and HPA axis function, and increase risk for negative stress-related health outcomes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.