Evidence map›Paper›PMID 30172922›Full record

ArticleNeurobiology of aging2018

Cerebral tract integrity relates to white matter hyperintensities, cortex volume, and cognition.

Stephan Seiler, Evan Fletcher, Kinsy Hassan-Ali, Michelle Weinstein, Alexa Beiser, Jayandra J Himali, Claudia L Satizabal, Sudha Seshadri, Charles DeCarli, Pauline Maillard

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of aging, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 1 pooled it
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.

  1. Pooled it
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  5. Brain White Matter Microstructure in Middle and Older Aged Adults With Bipolar Disorder: A 2-Site Study.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2026
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  6. Sub-Networks of the Brain RHuman brain mapping · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Stephan SeilerDepartment of Neurology, Center for Neurosciences, University of California at Davis, Davis, CA, USA; Imaging of Dementia and Aging (IDeA) Laboratory, University of California at Davis, Davis, CA, USA; Department of Neurology, Medical University Graz, Graz, Austria. Electronic address: sseiler@ucdavis.edu.
Evan FletcherDepartment of Neurology, Center for Neurosciences, University of California at Davis, Davis, CA, USA; Imaging of Dementia and Aging (IDeA) Laboratory, University of California at Davis, Davis, CA, USA.
Kinsy Hassan-AliDepartment of Neurology, Center for Neurosciences, University of California at Davis, Davis, CA, USA; Imaging of Dementia and Aging (IDeA) Laboratory, University of California at Davis, Davis, CA, USA.
Michelle WeinsteinDepartment of Neurology, Center for Neurosciences, University of California at Davis, Davis, CA, USA; Imaging of Dementia and Aging (IDeA) Laboratory, University of California at Davis, Davis, CA, USA.
Alexa BeiserThe Framingham Heart Study, Framingham, MA, USA; Department of Neurology, Boston University School of Medicine, Boston, MA, USA; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Jayandra J HimaliThe Framingham Heart Study, Framingham, MA, USA; Department of Neurology, Boston University School of Medicine, Boston, MA, USA; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Claudia L SatizabalThe Framingham Heart Study, Framingham, MA, USA; Department of Neurology, Boston University School of Medicine, Boston, MA, USA.
Sudha SeshadriThe Framingham Heart Study, Framingham, MA, USA; Department of Neurology, Boston University School of Medicine, Boston, MA, USA.
Charles DeCarliDepartment of Neurology, Center for Neurosciences, University of California at Davis, Davis, CA, USA; Imaging of Dementia and Aging (IDeA) Laboratory, University of California at Davis, Davis, CA, USA.
Pauline MaillardDepartment of Neurology, Center for Neurosciences, University of California at Davis, Davis, CA, USA; Imaging of Dementia and Aging (IDeA) Laboratory, University of California at Davis, Davis, CA, USA.
University of California, Davis · USBoston University · USCenter for Neurosciences · US

Funding

UC Davis Alzheimer's Disease Core CenterP30AG010129 · NIA · UNIVERSITY OF CALIFORNIA DAVIS · PI OLICHNEY, JOHN M · 1991 to 2020
$28.3M
PRECURSORS OF STROKE INCIDENCE AND PROGNOSISR01NS017950 · NINDS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Hugo Javier Aparicio, Jose Rafael Romero · 1985 to 2026
$22.9M
EPIDEMIOLOGY OF DEMENTIA IN THE FRAMINGHAM STUDYR01AG008122 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI AU, RHODA, SESHADRI, SUDHA · 1989 to 2015
$14.4M
Temporal Trends, Novel Imaging and Molecular Characterization of Preclinical and Clinical Alzheimer's Disease in the Framingham CohortsR01AG054076 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI DECARLI, CHARLES, SESHADRI, SUDHA · 2016 to 2020
$12.3M
MRI, Cognitive, Genetic & Biomarker Precursors of AD & Dementia in Young AdultsR01AG033040 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI AU, RHODA, SESHADRI, SUDHA · 2009 to 2019
$11.2M
Framingham: Inflammation, Genes &Cardiovascular DiseaseR01HL076784 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BENJAMIN, EMELIA J. · 2004 to 2008
$3.9M
Ventricular Vascular Coupling: Correlates and PrognosisR01HL080124 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI RAMACHANDRAN, VASAN S · 2005 to 2009
$3.4M
Microglial, Inflammatory and Omics Markers of Cerebral Small Vessel Disease in the CHARGE ConsortiumUH3NS100605 · NINDS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI FORNAGE, MYRIAM, SESHADRI, SUDHA · 2018 to 2020
$3.0M
CHARGE: Identifying Risk & Protective SNV for AD in ADSP Case-control SampleU01AG049505 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI SESHADRI, SUDHA · 2014 to 2017
$3.0M
Biomarkers of Ventricular and Vascular RemodelingR01HL077447 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI RAMACHANDRAN, VASAN S · 2005 to 2009
$2.6M
Aortic Dysfunction, Pulsatile Stress and Target Organ Damage in FraminghamR01HL107385 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI MITCHELL, GARY FRANK, RAMACHANDRAN, VASAN S · 2011 to 2014
$2.6M
Vascular Function in the Framingham Third GenerationR01HL070100 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BENJAMIN, EMELIA J. · 2002 to 2005
$2.4M
NHLBI NIH HHS HHSN268201500001INHLBI NIH HHS K23 HL118529NHLBI NIH HHS K24 HL004334NHLBI NIH HHS N01 HC025195NHLBI NIH HHS R01 HL060040NHLBI NIH HHS R01 HL070100NHLBI NIH HHS R01 HL071039NHLBI NIH HHS R01 HL076784NHLBI NIH HHS R01 HL077447NHLBI NIH HHS R01 HL080124NHLBI NIH HHS R01 HL107385NIA NIH HHS P30 AG010129NIA NIH HHS R01 AG008122NIA NIH HHS R01 AG028321NIA NIH HHS R01 AG033040NIA NIH HHS R01 AG054076NIA NIH HHS U01 AG049505NIA NIH HHS U01 AG052409NINDS NIH HHS R01 NS017950NINDS NIH HHS R01 NS071039NINDS NIH HHS UH3 NS100605
6 · The paper itself

Abstract

We examined the relationship among white matter (WM) tract integrity, WM hyperintensities (WMH), lobar gray matter (GM) volumes, and cognition in the cross-sectional Framingham Offspring Study. Six hundred eighty participants (71.7 ± 7.7 years) completed cognitive testing and magnetic resonance imaging. Diffusion tensor imaging probabilistic tractography was used to reconstruct major WM tracts. We computed tract-specific mean fractional anisotropy (FA) and tract-specific WMH ratio. Linear regressions identified relations between tracts and lobar GM volumes. Partial least squares regression examined associations between integrity of combined tracts, lobar GM volumes and cognition, including scores of memory and processing speed. Five tracts were particularly vulnerable to WMH, and tract-specific WMH volumes were inversely associated with tract-specific FA (p values < 0.05). Tract-specific FA related to lobar GM volumes. Memory was associated with lobar GM, while processing speed related to both tract integrity and lobar GM volumes. We conclude that subtle microstructural WM tract degeneration relates to specific lobar GM atrophy. The integrity of associated WM tracts and GM lobes differentially impacts memory and processing speed.

Indexed as

AgedAged, 80 and overAgingCerebral CortexCognitionCognitive AgingCognitive DysfunctionDiffusion Tensor ImagingFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedWhite MatterCognitive agingDiffusion tensor imagingMagnetic resonance imagingTractographyWhite matter hyperintensitiesWMH

Identifiers

PMID30172922
PMCPMC6242702
OpenAlexW2885089730

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.