Evidence map›Paper›PMID 30172857›Full record

ArticleThe Annals of thoracic surgery2018

Long-Term Survival After Arterial Versus Atrial Switch in d-Transposition of the Great Arteries.

Alexander Kiener, Michael Kelleman, Courtney McCracken, Lazaros Kochilas, James D St Louis, Matthew E Oster

Abstract readComparative Study
In one paragraph

Article in The Annals of thoracic surgery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 2 pooled it
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Long-Term Results After Senning and Mustard Operations for d-Transposition of the Great Arteries: Atrial Switch Should Remain in Armamentarium.European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery · 2026
    Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Alexander KienerDepartment of Pediatrics, Emory University School of Medicine, Atlanta, Georgia; Emory University Rollins School of Public Health, Atlanta, Georgia.
Michael KellemanDepartment of Pediatrics, Emory University School of Medicine, Atlanta, Georgia.
Courtney McCrackenDepartment of Pediatrics, Emory University School of Medicine, Atlanta, Georgia.
Lazaros KochilasDepartment of Pediatrics, Emory University School of Medicine, Atlanta, Georgia; Children's Healthcare of Atlanta, Atlanta, Georgia.
James D St LouisDepartment of Pediatric Surgery, University of Missouri-Kansas City School of Medicine, Kansas City, Missouri.
Matthew E OsterDepartment of Pediatrics, Emory University School of Medicine, Atlanta, Georgia; Emory University Rollins School of Public Health, Atlanta, Georgia; Children's Healthcare of Atlanta, Atlanta, Georgia. Electronic address: osterm@kidsheart.com.
Emory University · USChildren's Healthcare of Atlanta · USUniversity of Missouri–Kansas City · US

Funding

Long-term Outcomes after Interventions for Congenital Heart DiseaseR01HL122392 · NHLBI · UNIVERSITY OF MINNESOTA · PI KOCHILAS, LAZAROS K. · 2014 to 2022
$5.2M
NHLBI NIH HHS R01 HL122392
6 · The paper itself

Abstract

backgroundThe arterial switch operation (ASO) became the procedure of choice for dextro-transposition of the great arteries (d-TGA) nearly 30 years ago, but the long-term results of this operation are unknown. We aimed to compare the long-term transplant-free survival of patients with d-TGA who underwent ASO versus atrial switch in the Pediatric Cardiac Care Consortium.

methodsWe performed a retrospective cohort study of d-TGA patients undergoing ASO or atrial switch in the United States between 1982 and 1991. Long-term transplant-free survival was obtained by linking Pediatric Cardiac Care Consortium data with the National Death Index and the Organ Procurement and Transplant Network. Kaplan-Meier survival plots were constructed, and multivariable regression was used to compare long-term transplant-free survival.

resultsOf 554 d-TGA patients who underwent ASO (n = 259) or atrial switch (n = 295), the 20-year overall transplant-free survival was 82.1% for those undergoing ASO and 76.3% for those who had atrial switch procedure. Adjusted overall transplant-free survival beyond 10 years after operation was superior for ASO compared with atrial switch (hazard ratio 0.07, 95% confidence interval: 0.01 to 0.52, p = 0.009). During this period, the ASO had higher in-hospital mortality than the atrial switch (21.6% versus 12.9%, p = 0.007). After excluding patients with in-hospital mortality, the transplant-free survival 20 years after repair was 97.7% for the ASO patients versus 86.3% for the atrial switch patients.

conclusionsDespite initial higher in-hospital mortality for ASO during the study period, there is a significant long-term transplant-free survival advantage for ASO as compared with atrial switch for d-TGA surgery. Ongoing monitoring is required to assess late risk of cardiovascular disease.

Indexed as

Arterial Switch OperationCohort StudiesFemaleHospital MortalityHumansInfantInfant, NewbornMaleRetrospective StudiesSurvival RateTime FactorsTransposition of Great Vessels

Identifiers

PMID30172857
PMCPMC6240478
OpenAlexW2888883670

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.