ArticleBone2018
Vhl deficiency in osteocytes produces high bone mass and hematopoietic defects.
Open access · greenAbstract read
In one paragraph
Article in Bone, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 44 citations in OpenAlex.
- Dissecting Hypoxia Inducible Factor-Driven High Bone Mass Phenotype in Mice Lacking Osteocytic Von Hippel-Lindau.JBMR plus · 2026Article
- Oxygen-dependent osteocyte transcriptomic adaptations occur without modulation of endothelial gene expression via osteocyte paracrine signaling.JBMR plus · 2026Article
- Osteoporosis and Skeletal Fragility in non-Metastatic Pheochromocytomas and Paragangliomas: The Adrenergic-Skeletal Axis.Calcified tissue international · 2026Review
- Osteocyte-vascular Interactions in Bone Physiology and Pathology.Current osteoporosis reports · 2026Review
- Regional and Sexual Dimorphism in Murine Skeletal Responses to Osteocytic HIF Pathway Modulation.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2026Article
- Insights Into the HIF-1α-Mediated NLRP3 Pyroptosis Pathway in the Regulation of Musculoskeletal Diseases in the High-Altitude Environment.Journal of inflammation research · 2026Review
- The role of bone in whole-body energy metabolism.Nature reviews. Endocrinology · 2025Review
- Article
- Article
- Melanoma bone metastasis-induced osteocyte ferroptosis via the HIF1α-HMOX1 axis.Bone research · 2025Article
- A warming-yang herbal decoction protects against high-altitude hypoxia-induced osteoblast injury through modulation of HIF-1 signaling.Frontiers in pharmacology · 2025Article
- USP26 Combats Age-Related Declines in Self-Renewal and Multipotent Differentiation of BMSC by Maintaining Mitochondrial Homeostasis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Fibroblast Growth Factor 23 Bone Regulation and Downstream Hormonal Activity.Calcified tissue international · 2023Review
- Targeting osteocytes vs osteoblasts.Bone · 2023Review
- Degradation-Resistant Hypoxia Inducible Factor-2α in Murine Osteocytes Promotes a High Bone Mass Phenotype.JBMR plus · 2023Article
- Hypoxia-Inducible Factor-2α Signaling in the Skeletal System.JBMR plus · 2023Review
- Hypoxia Pathway in Osteoporosis: Laboratory Data for Clinical Prospects.International journal of environmental research and public health · 2023Review
- Review
- Osteoblast Lineage Support of Hematopoiesis in Health and Disease.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2022Review
- Deletion ofFrontiers in immunology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 1 country.
Gabriela G LootsLawrence Livermore National Laboratories, Physical and Life Sciences Directorate, Livermore, CA, USA; Molecular Cell Biology Unit, School of Natural Sciences, UC Merced, Merced, CA, USA.
Alexander G RoblingDepartment of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN, USA.
Jiun C ChangLawrence Livermore National Laboratories, Physical and Life Sciences Directorate, Livermore, CA, USA; Molecular Cell Biology Unit, School of Natural Sciences, UC Merced, Merced, CA, USA.
Deepa K MurugeshLawrence Livermore National Laboratories, Physical and Life Sciences Directorate, Livermore, CA, USA.
Jamila BajwaMolecular Cell Biology Unit, School of Natural Sciences, UC Merced, Merced, CA, USA.
Cameron CarlisleMolecular Cell Biology Unit, School of Natural Sciences, UC Merced, Merced, CA, USA.
Jennifer O ManilayMolecular Cell Biology Unit, School of Natural Sciences, UC Merced, Merced, CA, USA.
Alice WongDepartment of Anatomy, Physiology, and Cell Biology, School of Veterinary Medicine, University of California Davis, Davis, CA, USA.
Clare E YellowleyDepartment of Anatomy, Physiology, and Cell Biology, School of Veterinary Medicine, University of California Davis, Davis, CA, USA.
Damian C GenetosDepartment of Anatomy, Physiology, and Cell Biology, School of Veterinary Medicine, University of California Davis, Davis, CA, USA. Electronic address: dgenetos@ucdavis.edu.
Lawrence Livermore National Laboratory · USUniversity of California, Davis · USUniversity of California, Merced · USIndiana University School of Medicine
Funding
Lrp5 signaling in bone mechanotransduction and metabolismR01AR053237 · NIAMS · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI ALEXANDER G ROBLING, Matthew L Warman · 2005 to 2026
$9.4MIntegration of TGFb-ALK5 on Wnt signaling and mechanotransduction in boneR01AR064255 · NIAMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI GENETOS, DAMIAN C · 2013 to 2017
$1.7MRegulation of sclerostin expression by hypoxia: A proposed mechanism to explain hR03AR057547 · NIAMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI GENETOS, DAMIAN C · 2010 to 2012
$224kBLRD VA I01 BX001478NIAMS NIH HHS R01 AR053237NIAMS NIH HHS R01 AR064255NIAMS NIH HHS R03 AR057547
Abstract
Tissue oxygen (O
Indexed as
HematopoiesisAnimalsBone and BonesCancellous BoneCortical BoneGene DeletionHypoxia-Inducible Factor 1, alpha SubunitLymphopoiesisMice, Inbred C57BLOrgan SizeOsteocytesVon Hippel-Lindau Tumor Suppressor ProteinWnt Signaling PathwayHypoxia-Inducible Factor 1, alpha SubunitVon Hippel-Lindau Tumor Suppressor ProteinHematopoiesisHypoxia-inducible factorOsteocyteSclerostinvon Hippel-LandauWnt
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.