Evidence map›Paper›PMID 30172691›Full record

ArticleJournal of theoretical biology2018

Selection for synchronized cell division in simple multicellular organisms.

Jason Olejarz, Kamran Kaveh, Carl Veller, Martin A Nowak

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of theoretical biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jason OlejarzProgram for Evolutionary Dynamics, Harvard University, Cambridge, MA 02138, USA. Electronic address: jolejarz@fas.harvard.edu.
Kamran KavehProgram for Evolutionary Dynamics, Harvard University, Cambridge, MA 02138, USA. Electronic address: kkavehmaryan@fas.harvard.edu.
Carl VellerProgram for Evolutionary Dynamics, Harvard University, Cambridge, MA 02138, USA; Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA. Electronic address: carlveller@fas.harvard.edu.
Martin A NowakProgram for Evolutionary Dynamics, Harvard University, Cambridge, MA 02138, USA; Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA; Department of Mathematics, Harvard University, Cambridge, MA 02138, USA. Electronic address: martin_nowak@harvard.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The evolution of multicellularity was a major transition in the history of life on earth. Conditions under which multicellularity is favored have been studied theoretically and experimentally. But since the construction of a multicellular organism requires multiple rounds of cell division, a natural question is whether these cell divisions should be synchronous or not. We study a population model in which there compete simple multicellular organisms that grow by either synchronous or asynchronous cell divisions. We demonstrate that natural selection can act differently on synchronous and asynchronous cell division, and we offer intuition for why these phenotypes are generally not neutral variants of each other.

Indexed as

Evolution, MolecularModels, BiologicalSelection, GeneticCell CycleCell divisionEvolutionary dynamicsMulticellularitySynchronization

Identifiers

PMID30172691
PMCPMC6169303

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.