Trial reportThe Journal of pediatrics2018
Caregiving Disruptions Affect Growth and Pubertal Development in Early Adolescence in Institutionalized and Fostered Romanian Children: A Randomized Clinical Trial.
Trial report in The Journal of pediatrics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00747396 (The Bucharest Early Intervention Project), which is not on this map. Cited by 23 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Bucharest Early Intervention Project: Effects of Early Psychosocial Deprivation on Mental Health in Adolescence
Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 48 citations in OpenAlex.
- Parent-child separation and cardiometabolic outcomes and risk factors in adulthood: A systematic review.Psychoneuroendocrinology · 2023Pooled it
- Biological aging in childhood and adolescence following experiences of threat and deprivation: A systematic review and meta-analysis.Psychological bulletin · 2020Pooled it
- Physical and neurophysiological maturation associated with ADHD among previously institutionalized children: a randomized controlled trial.Journal of child psychology and psychiatry, and allied disciplines · 2025Trial
- Autonomic reactivity to social rejection, peer difficulties, and the buffering effects of adolescent friendships following early psychosocial deprivation.Emotion (Washington, D.C.) · 2022Trial
- Heightened sensitivity to the caregiving environment during adolescence: implications for recovery following early-life adversity.Journal of child psychology and psychiatry, and allied disciplines · 2021Trial
- Association between childhood weight status and timing of puberty: a systematic review and meta-analysis.Translational pediatrics · 2026Article
- Coming of age in war: Early life adversity, age at menarche, and mental health.Psychoneuroendocrinology · 2024Review
- Exploring sex differences in trajectories of pubertal development and mental health following early adversity.Psychoneuroendocrinology · 2024Article
- Mothers' prenatal distress accelerates adrenal pubertal development in daughters.Psychoneuroendocrinology · 2024Article
- Childhood trauma is linked to epigenetic age deceleration in young adults with previous youth residential care placements.European journal of psychotraumatology · 2024Article
- Pubertal timing, sex hormone levels, and associations between early life adversity and accelerated development amongst 11-year-old children of parents with schizophrenia or bipolar disorder and controls: The Danish high risk and Resilience study via 11.Comprehensive psychoneuroendocrinology · 2023Article
- Health of Post-Institutionalized Haitian Children Adopted to the United States.Maternal and child health journal · 2023Article
- Clinical and Pathological Manifestation of the Oral Mucosa in Institutionalized Children from Romania.International journal of environmental research and public health · 2022Article
- Adoption and trauma: Risks, recovery, and the lived experience of adoption.Child abuse & neglect · 2022Article
- Accelerated pubertal development as a mechanism linking trauma exposure with depression and anxiety in adolescence.Current opinion in psychology · 2022Review
- Agency, communion, and pubertal status: Separating between- and within-person associations to examine social goals development.Journal of personality · 2021Article
- Psychological Distress Symptoms and Resilience Assets in Adolescents in Residential Care.Children (Basel, Switzerland) · 2021Article
- Sex-Specific Associations Between Trauma Exposure, Pubertal Timing, and Anxiety in Black Children.Frontiers in human neuroscience · 2021Article
- The Correlation between Oral Self-Harm and Ethnicity in Institutionalized Children.Children (Basel, Switzerland) · 2020Article
- Can Children Catch up from the Consequences of Undernourishment? Evidence from Child Linear Growth, Developmental Epigenetics, and Brain and Neurocognitive Development.Advances in nutrition (Bethesda, Md.) · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 7 institutions in 2 countries.
Funding
Abstract
objectivesTo determine the effects of foster care vs institutional care, as well as disruptions in the caregiving environment on physical development through early adolescence. STUDY
designThis was a randomized controlled trial of 114 institutionalized, though otherwise healthy, children from 6 orphanages and 51 never institutionalized control children living in birth families (family care group) in Bucharest, Romania. Children were followed from baseline (21 months, range 5-31) through age 12 years for caregiving disruptions and growth trajectories and through age 14 years for pubertal development.
resultsChildren randomized to the foster care group showed greater rates of growth in height, weight, and body mass index (BMI) through age 12 years than institutionalized group. Tanner development was delayed in institutionalized group boys compared with foster care group and family care group boys at 12 but not 14 years. There were no differences in Tanner development and age of menarche among foster care group, institutionalized group, and family care group girls at ages 12 and 14 years. More disruptions in caregiving between 30 months and 12 years moderated decreases in growth rates of height in foster care group and weight in foster care group and institutionalized group across age. institutionalized group boys with ≥2 disruptions showed lower Tanner scores at age 12 vs institutionalized group and foster care group boys with <2 disruptions. foster care group girls with ≥2 disruptions had higher Tanner scores at age 14 vs foster care group girls with <2 disruptions. Age of menarche was not affected by caregiving disruptions.
conclusionsFor children who experienced early institutionalization, stable placement within family care is essential to ensuring the best outcomes for physical developmental.
trial registrationclinicaltrials.gov: NCT00747396.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.