Evidence map›Paper›PMID 30172258›Full record

ArticleJournal of medical case reports2018

Continuous infusion of lipo-prostaglandin E1 for Takayasu's arteritis with heart failure in an 11-month-old baby: a case report.

Ryo Higaki, Aya Miyazaki, Yujiro Tajiri, Mikihito Shoji, Shun Saito, Shin-Ichiro Yoshimura, Naoki Miki, Kazuhiro Hatta, Hiraku Doi

Open access · goldAbstract readCase Reports
In one paragraph

Article in Journal of medical case reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Overlap of Takayasu Arteritis and Kawasaki Disease in Infants.Chronic diseases and translational medicine · 2025
    Article
  3. Article
  4. Article
  5. Childhood-onset Takayasu Arteritis.European journal of rheumatology · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Ryo HigakiDepartment of Pediatrics, Tenri Hospital, 200 Mishima-cho, Tenri, Nara, 631-8552, Japan.
Aya MiyazakiDepartment of Pediatrics, Tenri Hospital, 200 Mishima-cho, Tenri, Nara, 631-8552, Japan. ayamiya@pc4.so-net.ne.jp.
Yujiro TajiriDepartment of Pediatrics, Tenri Hospital, 200 Mishima-cho, Tenri, Nara, 631-8552, Japan.
Mikihito ShojiDepartment of Pediatrics, Tenri Hospital, 200 Mishima-cho, Tenri, Nara, 631-8552, Japan.
Shun SaitoDepartment of Pediatrics, Tenri Hospital, 200 Mishima-cho, Tenri, Nara, 631-8552, Japan.
Shin-Ichiro YoshimuraDepartment of Pediatrics, Tenri Hospital, 200 Mishima-cho, Tenri, Nara, 631-8552, Japan.
Naoki MikiDepartment of Pediatrics, Tenri Hospital, 200 Mishima-cho, Tenri, Nara, 631-8552, Japan.
Kazuhiro HattaDepartment of Rheumatology, Tenri Hospital, 200 Mishima-cho, Tenri, Nara, 631-8552, Japan.
Hiraku DoiDepartment of Pediatrics, Tenri Hospital, 200 Mishima-cho, Tenri, Nara, 631-8552, Japan.
Tenri Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTakayasu's arteritis is extremely rare in children aged below 6 years. At the onset of Takayasu's arteritis in children, symptoms are varied but differ from those in adults. Corticosteroids are the mainstay of treatment for preventing irreversible vascular damage but there is no standard treatment for progressive vascular stenosis. CASE PRESENTATION: A Japanese 11-month-old baby boy presented with Takayasu's arteritis and heart failure, possibly due to afterload mismatch caused by high blood pressure. Computed tomography was performed and revealed thoracic and abdominal aortic aneurysms. It also revealed severe celiac artery stenosis and bilateral renal artery stenosis. Prednisolone was initiated as first-line therapy. The fever resolved, and C-reactive protein levels returned to normal. Although his general condition improved, deterioration of vascular lesions was evident. Celiac artery occlusion, severe right renal artery stenosis, and new superior mesenteric artery stenosis were observed. We decided to use a continuous infusion of lipo-prostaglandin E1 for prevention of branch stenosis of his abdominal aorta. The progression of vascular stenosis was stopped and our patient's cardiac function gradually improved.

conclusionsA differential diagnosis of heart failure with high blood pressure should be considered in babies. The progression of vascular stenosis may be suppressed by lipo-prostaglandin E1.

Indexed as

AlprostadilArterial Occlusive DiseasesHeart FailureHumansInfantMaleTakayasu ArteritisVasodilator AgentsAlprostadilVasodilator AgentsAbdominal vascular stenosisBabyHeart failureInfantLipo-prostaglandin E1Takayasu’s arteritis

Identifiers

PMID30172258
PMCPMC6119586
OpenAlexW2889299775

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.