Evidence map›Paper›PMID 30172192›Full record

ArticleEnvironmental research2018

Prenatal nitrate air pollution exposure and reduced child lung function: Timing and fetal sex effects.

Sonali Bose, Maria José Rosa, Yueh-Hsiu Mathilda Chiu, Hsiao-Hsien Leon Hsu, Qian Di, Alison Lee, Itai Kloog, Ander Wilson, Joel Schwartz, Robert O Wright and 3 more

Open access · hybridAbstract read
In one paragraph

Article in Environmental research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.1field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 42 citations in OpenAlex.

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  11. Review
  12. Treed distributed lag nonlinear models.Biostatistics (Oxford, England) · 2022
    Article
  13. Article
  14. Review
  15. Article
  16. The effect ofHealth policy OPEN · 2021
    Article
  17. Article
  18. Air pollution and lung function in children.The Journal of allergy and clinical immunology · 2021
    Review
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 2 countries.

Sonali BoseDivision of Pulmonary and Critical Care Medicine, Icahn School of Medicine at Mount Sinai, New York, United States; Department of Pediatrics, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1198, New York, NY 10029, United States.
Maria José RosaDepartment of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, United States.
Yueh-Hsiu Mathilda ChiuDepartment of Pediatrics, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1198, New York, NY 10029, United States.
Hsiao-Hsien Leon HsuDepartment of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, United States.
Qian DiDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, United States.
Alison LeeDivision of Pulmonary and Critical Care Medicine, Icahn School of Medicine at Mount Sinai, New York, United States.
Itai KloogDepartment of Geography and Environmental Development, Ben-Gurion University of the Negev, BeerSheba, Israel.
Ander WilsonDepartment of Statistics, Colorado State University, Fort Collins, CO, United States.
Joel SchwartzDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, United States.
Robert O WrightDepartment of Pediatrics, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1198, New York, NY 10029, United States; Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, United States; Institute for Exposomics Research, Icahn School of Medicine at Mount Sinai, New York, United States.
Wayne J MorganDepartment of Pediatrics, The University of Arizona, United States.
Brent A CoullDepartment of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, United States.
Rosalind J WrightDepartment of Pediatrics, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1198, New York, NY 10029, United States; Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, United States; Institute for Exposomics Research, Icahn School of Medicine at Mount Sinai, New York, United States. Electronic address: rosalind.wright@mssm.edu.
Icahn School of Medicine at Mount Sinai · USHarvard University · USBen-Gurion University of the Negev · ILColorado State University · USUniversity of Arizona · US

Funding

Translational Research Support CoreP30ES000002 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI JAIME ELIZABETH HART · 1985 to 2026
$44.6M
The Mount Sinai Transdisciplinary Center on Early Environmental ExposuresP30ES023515 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Chris Gennings · 2014 to 2026
$21.3M
GRADUATE TRAINING IN BIOSTATISTICST32ES007142 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI Brent Andrew Coull · 1985 to 2026
$11.9M
Research Training Program in Pediatric ExposomicsT32HD049311 · NICHD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KECIA Nicole CARROLL, Robert O Wright · 2007 to 2026
$7.4M
Stress, Environment, and Genetics in Urban AsthmaR01HL080674 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI WRIGHT, ROSALIND J · 2005 to 2014
$7.0M
MULTI-LEVEL ANALYSIS OF URBAN CHILDHOOD ASTHMA RISKR01ES010932 · NIEHS · BRIGHAM AND WOMEN'S HOSPITAL · PI WRIGHT, ROSALIND J · 2000 to 2004
$3.0M
Asthma Coalition on Community, Environment and StressU01HL072494 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI WRIGHT, ROSALIND J · 2002 to 2003
$1.5M
Prenatal PM2.5 and programming of respiratory outcomes: Placental biomarkers and effect modification by stressK23HL135349 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI LEE, ALISON G · 2017 to 2021
$884k
Ambient Air Pollution, Stress, Oxidative Markers and Respiratory Health in Mexican ChildrenR00ES027496 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI ROSA, MARIA JOSE · 2019 to 2021
$743k
Prenatal diet, PM2.5 and programming of the infant autonomic responseR21ES021318 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI WRIGHT, ROSALIND J · 2012 to 2014
$502k
NHLBI NIH HHS K23 HL135349NHLBI NIH HHS R01 HL080674NHLBI NIH HHS U01 HL072494NICHD NIH HHS T32 HD049311NIEHS NIH HHS P30 ES000002NIEHS NIH HHS P30 ES023515NIEHS NIH HHS R00 ES027496NIEHS NIH HHS R01 ES010932NIEHS NIH HHS R21 ES021318NIEHS NIH HHS T32 ES007142
6 · The paper itself

Abstract

backgroundPrenatal particulate air pollution exposure may alter lung growth and development in utero in a time-sensitive and sex-specific manner, resulting in reduced lung function in childhood. Such relationships have not been examined for nitrate (NO

methodsWe implemented Bayesian distributed lag interaction models (BDLIMs) to identify sensitive prenatal windows for the influence of NO

resultsMost mothers were Hispanic (65%) or Black (22%), had ≤ high school education (67%), and never smoked (71%); 17% children had asthma. BDILMs adjusted for maternal age and education and child's asthma identified an early sensitive window of 6-12 weeks gestation, during which increased NO

conclusionEarly gestational NO

Indexed as

Air PollutionPrenatal Exposure Delayed EffectsBayes TheoremChildFemaleForced Expiratory VolumeHumansLungMalePregnancyVital CapacityAir pollutionChildLung functionNitratePrenatal

Identifiers

PMID30172192
PMCPMC6196719
OpenAlexW2885030344

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.